Glofitamab

Glofitamab, sold under the brand name Columvi, is a bispecific monoclonal antibody used for the treatment of large B-cell lymphoma.[7] The most common side effects include cytokine release syndrome, muscle and bone pain, rash, and tiredness.[8][15] Glofitamab is indicated for the treatment of adults with relapsed or refractory diffuse large B-cell lymphoma.[11] The US Food and Drug Administration (FDA) label includes a boxed warning for serious or fatal cytokine release syndrome.[11] The trial was conducted at 32 sites in 13 of countries in Australia, Belgium, Canada, Czech Republic, Denmark, Spain, Finland, France, Italy, New Zealand, Poland, Taiwan, and the United States.
Monoclonal antibodyHumanizedTargetLicense dataDailyMedPregnancycategoryRoutes ofadministrationIntravenousDrug classAntineoplasticATC codeL01FX28Legal status ℞-onlyWARNINGCAS NumberDrugBankFormulaMolar massbispecific monoclonal antibodylarge B-cell lymphomaindicatedFood and Drug Administrationboxed warningCommittee for Medicinal Products for Human UseEuropean Medicines Agencyinternational nonproprietary nameHealth Canadapublic domainWorld Health OrganizationClinicalTrials.govMonoclonal antibodiesAdecatumumabAmivantamabAscrinvacumabAtezolizumab+hyaluronidaseCixutumumabConatumumabCosibelimabDaratumumabDrozitumabDuligotumabDusigitumabEnfortumab vedotinEnoticumabFigitumumabFlanvotumabGanitumabGlembatumumab vedotinIntetumumabIpilimumabIratumumabIstiratumabIcrucumabLexatumumabLucatumumabMapatumumabNarnatumabNecitumumabNesvacumabNivolumab+relatlimabOfatumumabOlaratumabPanitumumabPatritumabPembrolizumabPritumumabRadretumabRamucirumabRilotumumabRobatumumabSeribantumabSugemalimabTarextumabTisotumab vedotinTeprotumumabTovetumabVantictumabVotumumabZalutumumabAbagovomabAltumomab pentetateAnatumomab mafenatoxArcitumomabBectumomabBlinatumomabCapromab pendetideDetumomabEdrecolomabIbritumomab tiuxetanIgovomabLilotomabMinretumomabMitumomabNacolomab tafenatoxMoxetumomab pasudotoxNaptumomab estafenatoxOregovomabPemtumomabRacotumomabSatumomab pendetideSolitomabTaplitumomab paptoxNofetumomab merpentanPintumomabTenatumomabTositumomabChimericAmatuximabBavituximabBrentuximab vedotinCarotuximabCetuximabDerlotuximab biotinDinutuximabEcromeximabEnsituximabFutuximabGirentuximabIndatuximab ravtansineIsatuximabLoncastuximab tesirineMargetuximabMirvetuximab soravtansineRituximabSiltuximabUblituximabZolbetuximabAbituzumabAlemtuzumabAxatilimabBelantamab mafodotinBevacizumabBivatuzumab mertansineBrontictuzumabCantuzumab mertansineCantuzumab ravtansineCirmtuzumabCitatuzumab bogatoxClivatuzumab tetraxetanCofetuzumab pelidotinDacetuzumabDemcizumabDalotuzumabDatopotamab deruxtecanDenintuzumab mafodotinElotuzumabEmactuzumabEmibetuzumabEnoblituzumabEpcoritamabEtaracizumabFarletuzumabFiclatuzumabFlotetuzumabGemtuzumab ozogamicinImgatuzumabInotuzumab ozogamicinLabetuzumabLifastuzumab vedotinLintuzumabLorvotuzumab mertansineLumretuzumabMatuzumabMilatuzumabNaxitamabNimotuzumabObinutuzumabOcaratuzumabOdronextamabOtlertuzumabOnartuzumabOportuzumab monatoxParsatuzumabPertuzumabPinatuzumab vedotinPolatuzumab vedotinRosmantuzumabRovalpituzumab tesirineSacituzumab govitecanSibrotuzumabSimtuzumabSofituzumab vedotinTacatuzumab tetraxetanTigatuzumabTrastuzumab+deruxtecan+emtansineTucotuzumab celmoleukinVandortuzumab vedotinVanucizumabVeltuzumabVorsetuzumab mafodotinZenocutuzumabRat/mouse hybridCatumaxomabErtumaxomabDepatuxizumab mafodotinDuvortuxizumabOntuxizumabWHO-EMWithdrawnClinical trialsTargeted cancer therapyantineoplastic agentsReceptor tyrosine kinaseHER1/EGFRHER2/neuTrastuzumab emtansineTrastuzumab deruxtecanZanidatamabVEGF-ALeukemialymphomalymphoidElranatamabMosunetuzumabIbritumomabBrentuximabmyeloidAvelumabBermekimabCemiplimabDinutuximab betaDostarlimabDurvalumabMogamulizumabRetifanlimabSerplulimabTafasitamabTalquetamabTarlatamabTeclistamabTislelizumabToripalimabTremelimumabTyrosine kinase inhibitorsAfatinibAumolertinibBrigatinibDacomitinibErlotinibGefitinibIcotinibLazertinibMobocertinibOlmutinibOsimertinibRociletinibVandetanibLapatinibNeratinibTucatinibDabrafenibEncorafenibTovorafenibVemurafenibRTK class IIIAvapritinibAxitinibMasitinibPazopanibRipretinibSorafenibSunitinibToceranibLestaurtinibGilteritinibCediranibFruquintinibLenvatinibNintedanibRegorafenibSemaxanibTivozanibAlectinibCeritinibCrizotinibEnsartinibLorlatinibEntrectinibFutibatinibInfigratinibLarotrectinibPemigatinibPralsetinibRepotrectinibSelpercatinibCabozantinibCapmatinibNon-receptorbcr-ablAsciminibBosutinibDasatinibImatinibNilotinibPonatinibRadotinibJanus kinaseBaricitinibFedratinibFilgotinibMomelotinibPacritinibRuxolitinibBinimetinibCobimetinibSelumetinibTrametinibBruton'sAcalabrutinibIbrutinibOrelabrutinibPirtobrutinibZanubrutinibfusion proteinAfliberceptproapoptoticprohibitinAdipotideexotoxinDenileukin diftitoxmTOR inhibitorsEverolimusRidaforolimusSirolimusTemsirolimushedgehogGlasdegibSonidegibVismodegibCDK inhibitorsAbemaciclibDalpiciclibPalbociclibRibociclibTrilaciclibAdagrasibSotorasibPi3K inhibitorsAlpelisibCopanlisibDuvelisibIdelalisibInavolisibParsaclisibRevumenibFibroblast growth factor receptorErdafitinibMidostaurinPexidartinibQuizartinibTebentafuspTepotinibTunlametinibVenetoclax