Mytatrienediol

Mytatrienediol (developmental code name SC-6924; former tentative brand names Manvene, Anvene), also known as 16α-methyl-16β-epiestriol 3-methyl ether or 16β-hydroxy-16α-methylestradiol 3-methyl ether, is a synthetic steroidal estrogen medication and an estrogen ether which was derived from estriol and was developed for clinical use in the late 1950s but was never marketed.[1] It was investigated as a weak and mildly estrogenic medication for men to treat atherosclerosis, improve serum lipid profiles, and reduce the risk of myocardial infarction.[2][3][4][5][6][7] However, while preclinical research supported the profile of mytatriendiol as a weak estrogen, the medication was found in clinical trials to produce estrogenic side effects including feminization, breast pain, and gynecomastia in men similarly and comparably to other estrogens such as ethinylestradiol and conjugated estrogens, and its side effects ultimately precluded its use.[8][3][2] The medication was also studied to treat bone pain in patients with multiple myeloma, metastatic bone disease, and osteoporosis, with effectiveness seen.You can help Wikipedia by expanding it.This drug article relating to the genito-urinary system is a stub.
Routes ofadministrationBy mouthDrug classEstrogenEstrogen etherIUPAC nameCAS NumberChemSpiderCompTox DashboardFormulaMolar massSMILESsyntheticsteroidalestriolatherosclerosislipid profilesmyocardial infarctionpreclinical researchclinical trialsside effectsfeminizationbreast paingynecomastiaethinylestradiolconjugated estrogensbone painmultiple myelomametastatic bone diseaseosteoporosisSC-4289TriparanolEstrogen receptormodulators2-Hydroxyestradiol2-Hydroxyestrone3-Methyl-19-methyleneandrosta-3,5-dien-17β-ol3α-Androstanediol3α-Hydroxytibolone3β-Hydroxytibolone3β-Androstanediol4-Androstenediol4-Androstenedione4-Fluoroestradiol4-Hydroxyestradiol4-Hydroxyestrone4-Methoxyestradiol4-Methoxyestrone5-Androstenediol7-Oxo-DHEA7α-Hydroxy-DHEA7α-Methylestradiol7β-Hydroxyepiandrosterone8,9-Dehydroestradiol8,9-Dehydroestrone8β-VE210β,17β-Dihydroxyestra-1,4-dien-3-one (DHED)11β-Chloromethylestradiol11β-Methoxyestradiol15α-Hydroxyestradiol16-Ketoestradiol16-Ketoestrone16α-Fluoroestradiol16α-Hydroxy-DHEA16α-Hydroxyestrone16α-Iodoestradiol16α-LE216β-Hydroxyestrone16β,17α-Epiestriol (16β-hydroxy-17α-estradiol)17α-Estradiolalfatradiol17α-Dihydroequilenin17α-Dihydroequilin17α-Epiestriol (16α-hydroxy-17α-estradiol)17α-Ethynyl-3α-androstanediol17α-Ethynyl-3β-androstanediol17β-Dihydroequilenin17β-Dihydroequilin17β-Methyl-17α-dihydroequileninAbirateroneAbiraterone acetateAlestramustineAlmestroneAnabolic steroidstestosteronemethyltestosteronemetandienone (methandrostenolone)nandroloneAtrimustineBolandiolBolandiol dipropionateButolameClomestroneCloxestradiolCloxestradiol acetateConjugated estriolCyclodiolCyclotriolDHEA-Sent-EstradiolEpiestriol (16β-epiestriol, 16β-hydroxy-17β-estradiol)EpimestrolEquileninEquilinERA-63 (ORG-37663)Esterified estrogensEstetrolEstradiolLipoidal estradiolPolyestradiol phosphateEstramustineEstramustine phosphateEstrapronicateEstrazinolPolyestriol phosphateEstrofurateEstrogenic substancesEstromustineEstroneEstrone methyl etherEstropipateEtamestrol (eptamestrol)EthinylandrostenediolEthandrostateEthinylestradiol 3-benzoateEthinylestradiol sulfonateEthinylestriolEthylestradiolEtynodiolEtynodiol diacetateHexolameHippulinHydroxyestrone diacetateLynestrenolLynestrenol phenylpropionateMestranolMethylestradiolMoxestrolNilestriolNorethisteroneNoretynodrelOrestratePentolameProdiameProlamePromestrieneRU-16117QuinestradolQuinestrolTibolone(R,R)-THC(S,S)-THC2,8-DHHHCβ-LGND2 (GTx-878)AllenestrolAllenolic acidBenzestrolBifluranolBisdehydrodoisynolic acidButestrolCarbestrolD-15414DCW234DiarylpropionitrileDienestrolDienestrol diacetateDiethylstilbestrolDimestrol (dianisylhexene)DimethylstilbestrolDoisynoestrol (fenocycline)Doisynolic acidEfavirenzElacestrantERB-196 (WAY-202196)Erteberel (SERBA-1, LY-500307)Estrobin (DBE)FenestrelFERb 033Fosfestrol (diethylstilbestrol diphosphate)Furostilbestrol (diethylstilbestrol difuroate)GTx-758HexestrolICI-85966 (Stilbostat)meso-Butestrolmeso-HexestrolMestilbolMethallenestrilMethestrolMethestrol dipropionateParoxypropionePentafluranolPhenestrolPrinaberel (ERB-041, WAY-202041)PropylpyrazoletriolQuadrosilanSERBA-2SKF-82,958TerfluranolTriphenylbromoethyleneTriphenylchloroethyleneTriphenyliodoethyleneTriphenylmethylethylene (triphenylpropene)WAY-166818WAY-200070WAY-204688 (SIM-688)WAY-214156ERB-26ERA-45ERB-79ZK-283197anetholedianetholedianolphotoanetholeChalconoidsisoliquiritigeninphloretinphlorizin (phloridzin)wedelolactoneCoumestanscoumestrolpsoralidinFlavonoids7,8-DHF8-prenylnaringeninapigeninbaicaleinbaicalinbiochanin AcalycosincatechindaidzeindaidzinepicatechinformononetinglabreneglabridingenisteingenistinglyciteinkaempferolliquiritigeninmirificinmyricetinnaringeninpinocembrinprunetinpuerarinquercetintectoridintectorigeninLavender oilLignansenterodiolenterolactonenyasol (cis-hinokiresinol)MetalloestrogenscadmiumPesticidesalternarioldieldrinendosulfanfenarimolmethiocarbmethoxychlortriclocarbantriclosanPhytosteroidsdigitoxindigitalisdiosgeninguggulsteronePhytosterolsβ-sitosterolcampesterolstigmasterolResorcylic acid lactoneszearalanoneα-zearalenolβ-zearalenolzearalenonezeranol (α-zearalanol)taleranol (teranol, β-zearalanol)SteroiddeoxymiroestrolmiroestrolStilbenoidsresveratrolrhaponticinSynthetic xenoestrogensalkylphenolsbisphenolsparabensphthalatesagnuside2-Phenylbenzofuran4'-Hydroxynorendoxifen27-HydroxycholesterolAcefluranolAcolbifeneAfimoxifeneAnordiolAnordrinArzoxifeneBazedoxifeneBrilanestrantBroparestrolCamizestrantChlorotrianiseneClomifeneClomifenoxideCyclofenilDesmethylchlorotrianiseneDroloxifeneEnclomifeneEndoxifenEtacstil (GW-5638, DPC-974)Ethamoxytriphetol (MER-25)FemarelleFispemifeneICI-55548IdoxifeneLasofoxifeneLevormeloxifeneLN-1643LN-2299MenerbaMiproxifeneMiproxifene phosphateNafoxidineNitromifeneNNC 45-0095OrmeloxifeneOspemifenePanomifenePipendoxifeneRaloxifeneRimostil (P-081)SpironolactoneTamoxifenTAS-108 (SR-16234)ToremifeneTrioxifeneZindoxifeneZuclomifene7β-Hydroxy-DHEACytestrol acetateEpitiostanolFulvestrant (ICI-182780)GlyceollinsICI-164384MepitiostaneMethylepitiostanolMethylpiperidinopyrazolePhenytoinProchlorazERX-11Trilostane2-MethoxyestradiolAfimoxifene (4-hydroxytamoxifen)AldosteroneAtrazineBisphenol Ap,p'-DDTHydroxytyrosolKeponeNicotinic acidNicotinamideNonylphenolOleuropeinList of estrogensgenito-urinary system