Fosfestrol
Fosfestrol, sold under the brand name Honvan and also known as diethylstilbestrol diphosphate (DESDP), is an estrogen medication which is used in the treatment of prostate cancer in men.[3][2] Side effects of fosfestrol include nausea and vomiting, cardiovascular complications, blood clots, edema, and genital skin reactions, among others.[9] Fosfestrol sodium is given at a dosage of 600 to 1200 mg/day by slow intravenous infusion over a period of 1 hour for a treatment duration of 5 to 10 days in men with prostate cancer.[3] Fosfestrol sodium is also used to a lesser extent by oral administration initially at a dosage of 360 to 480 mg three times per day in the treatment of prostate cancer.[10] Side effects of fosfestrol include nausea and vomiting in 80% of patients (with 1 in 25 cases, or 4%, resulting in death), cardiovascular complications (18% with fosfestrol plus adriamycin relative to 2% with adriamycin alone) such as thrombosis (2 in 25 cases, or 8%), edema (44% requiring diuretic therapy), and skin reactions such as burning, itching, or pain in the genital area (40%).[15][7][8][3] Brand names of fosfestrol include Cytonal, Difostilben, Honovan, Honvan, Honvol, Honvon, Fosfostilben, Fostrolin, ST 52, Stilbetin, Stilbol, Stilbostatin, Stilphostrol, and Vagestrol, among others.
Drugs.comRoutes ofadministrationIntravenousby mouthDrug classNonsteroidal estrogenEstrogen esterATC codeL02AA04Legal statusIUPAC nameCAS NumbertetrasodiumChemSpiderChEMBLCompTox DashboardECHA InfoCardFormulaMolar massSMILESestrogenprostate cancerintravenous infusionSide effectsnauseavomitingcardiovascularblood clotsgenitalskin reactionsagonistestrogen receptorbiological targetestrogensestradiolprodrugdiethylstilbestrolhigh-dose estrogencastration-resistant prostate cancermetastasesorchiectomygonadotropin-releasing hormone modulatorsnonsteroidal antiandrogenstestosteronegonadotropin-releasing hormone agonistoral administrationConjugated estrogensEthinylestradiolEthinylestradiol sulfonateDienestrolHexestrolChlorotrianiseneQuadrosilanEstramustine phosphateTransdermal patchSC injectionEstradiol benzoateEstradiol dipropionateEstradiol valerateEstradiol undecylatePolyestradiol phosphateEstroneIV injectionsolutionstabletsadriamycinthrombosisdiureticburningitchingweight gainfeminizationgynecomastiaradioimmunoassayestrogen receptorsantigonadotropiccastratecytotoxicprostate glandpharmacokineticssyntheticstilbestroldiphosphatefree basetetrasodium saltpolymerpolydiethylstilbestrol phosphateveterinary medicinepatentedwater-solubleintravenous administrationUnited StatesFrancegeneric nameCanadaEuropeLatin AmericaSouth AfricaBangladeshTunisiaantiestrogensAlfatradiolandrogensanabolic steroidsmethyltestosteronemetandienoneprogestinsnorethisteronenoretynodreletynodiol diacetatetiboloneClomestroneCloxestradiol acetateConjugated estriolEpiestriolEpimestrolEsterified estrogensEstetrolestradiol acetateestradiol cypionateestradiol enanthateestradiol ester mixturesClimacteronEstriolestriol succinatepolyestriol phosphate