They form the central core for a variety of important biological compounds.Some chalconoids demonstrated the ability to block voltage-dependent potassium channels.[2] Chalcones are aromatic ketones with two phenyl rings that are also intermediates in the synthesis of many biological compounds.[3] Flavonoids are substances in the plant's secondary metabolism with an array of biological activities.Naringenin-chalcone synthase uses malonyl-CoA and 4-coumaroyl-CoA to produce CoA, naringenin chalcone, and CO2.