2-Phenylbenzofuran

2-Phenylbenzofuran (2-phenyl-benzo[b]furan) is a chemical compound that has the molecular formula C14H10O.It is a substituted benzofuran, with a phenyl group as the substituent.2-Phenylbenzofuran is a natural product, and its derivatives (known as 2-phenylbenzofurans) have been isolated from various plants, such as Artocarpus pithecogallus,[2] legumes, and mulberries.[3][4] Because there is a substituent at position 2, this benzofuran compound cannot be synthesized by the Perkin rearrangement from a coumarin.However, an alternate sequence has been demonstrated: treatment of 3-phenylcoumarin with aluminium hydride followed by DDQ:[3] 2-Phenylbenzofuran and its derivatives have been the subject of research on antioxidant drugs,[5][2] butyrylcholinesterase inhibition,[6] and leishmaniasis treatment.
IUPAC nameCAS NumberChEMBLChemSpiderEC NumberPubChemCompTox DashboardSMILESChemical formulaMolar massGHS labellingPictogramsHazard statementsPrecautionary statementsstandard statesubstituted benzofuranphenyl groupsubstituentlegumesmulberriesPerkin rearrangementcoumarinaluminium hydrideantioxidantbutyrylcholinesteraseleishmaniasisBibcode