γ-Amanitin
It is an amatoxin, a group of toxins isolated from and found in several members of the mushroom genus Amanita, one being the death cap (Amanita phalloides) as well as the destroying angel, a complex of similar species, principally A. virosa and A. bisporigera.The compound is highly toxic, inhibits RNA polymerase II, disrupts synthesis of mRNA, and can be fatal.[1] Amatoxins selectively inhibit Eukaryotic RNA polymerase II by tightly to the enzyme and severely inhibits translocation along the DNA template; thus the synthesis of mRNA and proteins stops.[2] Amatoxin consumption is characterized by a long asymptomatic period of a few hours (up to a day or more) followed by quick physiological decline due to acute hepatic and tubular necrosis.[3] γ-Amanitin has been found to have similar levels of toxicity to other amatoxins such as α-Amanitin.
CAS NumberChemSpiderPubChemCompTox DashboardSMILESChemical formulaMolar massstandard statecyclic peptideamino acidsamatoxintoxinsmushroomAmanitaAmanita phalloidesdestroying angelA. virosaA. bisporigeraRNA polymerase IIMushroom poisoningA. albocreataA. crenulataA. farinosaA. frostianaA. gemmataA. ibotengutakeA. multisquamosaA. muscariaA. pantherinaA. porphyriaA. regalisA. strobiliformisA. xanthocephalaIbotenic AcidMuscimolMuscarineMuscazoneAmavadineSaproamanitaA. thiersiiDestroying angelsA. exitialisA. magnivelarisA. ocreataA. vernaA. virosiformisA. arocheaeA. fuligineaA. pallidoroseaA. phalloidesA. rimosaA. subjunquilleaAmatoxinsAmanitinsalpha-gamma-epsilon-AmanullinAmanullinic acidAmaninamideAmaninProamanullinPhallotoxinsPhalloidinVirotoxinsAntamanidePhallolysinA. proximaA. smithianaA. sphaerobulbosaA. rubescenscardiotoxincytotoxinenterotoxinhemotoxinhepatotoxinneurotoxinphototoxinBacterial toxinsExotoxinGram positiveBacilliClostridiumtetaniTetanospasminTetanolysinperfringensAlpha toxindifficilebotulinumAnthrax toxinListeriolysin OStreptolysinLeukocidinPanton–Valentine leukocidinStaphylococcusStaphylococcus aureus alphaExfoliatinToxic shock syndrome toxinStaphylococcal Enterotoxin B (SEB)ActinomycetotaCord factorDiphtheria toxinGram negativeShiga toxinE. coli heat-stable enterotoxinCholera toxinHeat-labile enterotoxinPertussis toxinPseudomonas exotoxinExtracellular adenylate cyclaseSuperantigenPore-forming toxinAB toxinEndotoxinLipopolysaccharideLipid ABacillus thuringiensis delta endotoxinCry1AcCry3Bb1Cry6AaCry34Ab1Virulence factorClumping factor AFibronectin binding protein AMycotoxins