Amanullin
It is an amatoxin, all of which are found in several members of the mushroom genus Amanita.The oral LD50 of amanullin is approximately 20 mg/kg in mice; however, it is non-toxic in humans.Like other amatoxins, amanullin is an inhibitor of RNA polymerase II.Amanullin has a species dependent and specific attraction to the enzyme RNA polymerase II.Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).
CAS NumberChemSpiderPubChemCompTox DashboardSMILESChemical formulaMolar massSolubility in waterSolubilityethanolmethanolstandard statecyclic peptideamatoxinmushroomAmanitaamatoxinsRNA polymerase IIcytolysishepatocytesMushroom poisoningWayback MachineA. albocreataA. crenulataA. farinosaA. frostianaA. gemmataA. ibotengutakeA. multisquamosaA. muscariaA. pantherinaA. porphyriaA. regalisA. strobiliformisA. xanthocephalaIbotenic AcidMuscimolMuscarineMuscazoneAmavadineSaproamanitaA. thiersiiDestroying angelsA. bisporigeraA. exitialisA. magnivelarisA. ocreataA. vernaA. virosaA. virosiformisA. arocheaeA. fuligineaA. pallidoroseaA. phalloidesA. rimosaA. subjunquilleaAmanitinsalpha-gamma-epsilon-Amanullinic acidAmaninamideAmaninProamanullinPhallotoxinsPhalloidinVirotoxinsAntamanidePhallolysinA. proximaA. smithianaA. sphaerobulbosaA. rubescensToxinscardiotoxincytotoxinenterotoxinhemotoxinhepatotoxinneurotoxinphototoxinBacterial toxinsExotoxinGram positiveBacilliClostridiumtetaniTetanospasminTetanolysinperfringensAlpha toxindifficilebotulinumAnthrax toxinListeriolysin OStreptolysinLeukocidinPanton–Valentine leukocidinStaphylococcusStaphylococcus aureus alphaExfoliatinToxic shock syndrome toxinStaphylococcal Enterotoxin B (SEB)ActinomycetotaCord factorDiphtheria toxinGram negativeShiga toxinE. coli heat-stable enterotoxinCholera toxinHeat-labile enterotoxinPertussis toxinPseudomonas exotoxinExtracellular adenylate cyclaseSuperantigenPore-forming toxinAB toxinEndotoxinLipopolysaccharideLipid ABacillus thuringiensis delta endotoxinCry1AcCry3Bb1Cry6AaCry34Ab1Virulence factor