Vanillotoxin
Vanillotoxins (VaTxs, subtypes VaTx1, VaTx2, and VaTx3) are neurotoxins found in the venom of the tarantula Psalmopoeus cambridgei.They act as agonists for the transient receptor potential cation channel subfamily V member 1 (TRPV1), activating the pain sensory system.VaTx1 and 2 also act as antagonists for the Kv2-type voltage-gated potassium channel (Kv2), inducing paralytic behavior in small animals.In general, the venom of P. cambridgei is known to produce pain, but the amount of toxin that is present in a bite is too low to cause serious health problems[1] .[3] By doing so, they increase the action potential threshold in the neuromuscular junction, eliciting paralytic behavior.
ChemSpiderIUPHAR/BPSSMILESMolar massstandard stateneurotoxinstarantulaPsalmopoeus cambridgeiagoniststransient receptor potential cation channelTrinidadinhibitor cystine knotKv2 channelperipheral nervous systemneuromuscular junctionBibcodeToxinscardiotoxincytotoxinenterotoxinhemotoxinhepatotoxinneurotoxinphototoxinBacterial toxinsExotoxinGram positiveBacilliClostridiumtetaniTetanospasminTetanolysinperfringensAlpha toxindifficilebotulinumAnthrax toxinListeriolysin OStreptolysinLeukocidinPanton–Valentine leukocidinStaphylococcusStaphylococcus aureus alphaExfoliatinToxic shock syndrome toxinStaphylococcal Enterotoxin B (SEB)ActinomycetotaCord factorDiphtheria toxinGram negativeShiga toxinE. coli heat-stable enterotoxinCholera toxinHeat-labile enterotoxinPertussis toxinPseudomonas exotoxinExtracellular adenylate cyclaseSuperantigenPore-forming toxinAB toxinEndotoxinLipopolysaccharideLipid ABacillus thuringiensis delta endotoxinCry1AcCry3Bb1Cry6AaCry34Ab1Virulence factorClumping factor AFibronectin binding protein AMycotoxinsAflatoxinAmatoxinalpha-amanitinbeta-amanitingamma-amanitinepsilon-amanitinbeta-Nitropropionic acidCitrininCytochalasinErgotamineFumonisinFumonisin B1Fumonisin B2Fumonisin B4GliotoxinIbotenic acidLolitrem BMuscimolOrellanineOchratoxinPatulinPhalloidinSterigmatocystinTrichotheceneVomitoxinZeranolZearalenoneAmygdalinAnisatinAntiarinBrucineChaconineCicutoxinConiineDaphninDelphinineDivicineDjenkolic acidFalcarinolGossypolHelenalinLinamarinLotaustralinMimosineOenanthotoxinOleandrinPersinProtoanemoninPseudaconitineRetronecineResiniferatoxinScopolamineSolamargineSolanidine