Linear IgA bullous dermatosis

Linear IgA bullous dermatosis is a rare immune-mediated blistering skin disease frequently associated with medication exposure, especially vancomycin, with men and women being equally affected.[6] Skin lesions typically occur in a wide range of locations, including the hands, feet, genitalia, trunk, and face, especially the perioral area.Adults experience a lower incidence of developing annular lesions exhibiting peripheral vesiculation compared to children.[13] There have also been reports of localized variations of LABD that manifest as annular inflammatory plaques or restricted blistering eruptions.[24] Many case reports have documented the incidence of LABD in conjunction with solid organ cancers and lymphoproliferative diseases.[39][40] IgA antibodies directed against various basement membrane antigens, such as type VII collagen (COL7), laminin-332, or laminin gamma 1, are present in certain patients with LABD.[10] Linear IgA bullous dermatosis histopathologic features are vague and frequently mimic dermatitis herpetiformis.[10] First-line treatment for LABD is thought to be dapsone, an immunomodulatory sulfone that has been successfully used to treat a variety of dermatologic illnesses marked by neutrophilic infiltrates.
SpecialtyImmunologydermatologyvancomycinTadeusz Chorzelskiautoimmunedermatitis herpetiformispemphigoidrituximabmucous membranesblistersprurituspapulesprurigo nodularismucous membraneconjunctivapharynxlarynxesophaguscheilitisgingivitislamina lucidaulcerative colitislymphoproliferative diseasesPsoriasissystemic lupus erythematosusUV radiationantibioticsnonsteroidal anti-inflammatory medicationslithiumamiodaronecaptoprilcyclosporinephenytoininterferon alfafurosemidesomatostatintumor necrosis factorhuman leukocyte antigenbasement membrane zoneneutrophilsbasement membranetype XVII collagentype VII collagenlaminin-332laminin gamma 1immunofluorescenceeosinophilslymphocytesdapsonesulfonesulfapyridinesulfamethoxypyridazinesulfonamideMicrographList of target antigens in pemphigoidList of immunofluorescence findings for autoimmune bullous conditionsDiseasesDBSNOMED CTeMedicinePatient UKOrphanetVesiculobullous diseaseAcantholysisepidermisPemphigusPemphigus vulgarisPemphigus vegetansof Hallopeauof NeumannPemphigus foliaceusPemphigus erythematosusEndemic pemphigusParaneoplastic pemphigusIgA pemphigusSubcorneal pustularIntraepidermal neutrophilicTransient acantholytic dermatosisdermisBullous pemphigoidCicatricial pemphigoidLocalisedGestational pemphigoidPemphigoid nodularisEpidermolysis bullosa acquisitaChildhoodbullousPorphyria cutanea tardaBullous lupus erythematosusPUVA-induced acrobullous dermatosis