Pemphigus foliaceus

[1] Pemphigus foliaceus causes a characteristic inflammatory attack at the subcorneal layer of epidermis, which results in skin lesions that are scaly or crusted erosions with an erythematous (red) base.[citation needed] The differential diagnosis includes other forms of pemphigus, bullous impetigo, subcorneal pustular dermatosis, subacute cutaneous LE, and seborrheic dermatitis.As discussed earlier, the demonstration of IgG autoantibodies against epidermal cell surfaces is essential for separating these disorders from the pemphigus family.In general, immunosuppressive agents, such as azathioprine, mycophenolate mofetil and cyclophosphamide, when combined with corticosteroids, may result in gaining early control of the disease and an increased percentage of clinical remissions.However, fogo selvagem occurs in an endemic fashion in certain regions of Brazil (especially along inland riverbeds)[2] and is thought to be caused by an environmental factor(s).
SpecialtyDermatologyautoimmuneepidermiserythematousMucosalantibodiesdesmoglein 1keratinocyteadhesiondesmosomeacantholysisNational Institute of Arthritis and Musculoskeletal and Skin Diseasesimmune systempemphigus vulgariserythrodermabullous impetigoseborrheic dermatitistinea corporisazathioprinemycophenolate mofetilcyclophosphamidePierre Louis Alphée CazenaveList of cutaneous conditionsPemphigusMcGraw-HillElsevierDiseasesDBOrphanetVesiculobullous diseasePemphigus vegetansof Hallopeauof NeumannPemphigus erythematosusEndemic pemphigusParaneoplastic pemphigusIgA pemphigusSubcorneal pustularIntraepidermal neutrophilicTransient acantholytic dermatosisPemphigoiddermisBullous pemphigoidCicatricial pemphigoidLocalisedGestational pemphigoidPemphigoid nodularisEpidermolysis bullosa acquisitaLinear IgA bullous dermatosisChildhoodbullousDermatitis herpetiformisPorphyria cutanea tardaBullous lupus erythematosusPUVA-induced acrobullous dermatosis