C-fos-induced growth factor
This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3 receptors.The structure and function of this protein is similar to those of vascular endothelial growth factor C.[5] Lymph node metastasis is very often associated with several types of human malignancies.Cancer cells’ journey to lymph node takes place largely through lymphatic tunnel located in and around of primary tumor.VEGF-D has been established to be over-expressed in both tumor tissues and patients’ serum samples in several types of human cancer.In experimental mice study, genetically modified tumor cell that was forced to produce VEGF-D protein have been established to boost up regional lymph nodes metastases.