Golgi cell

In vivo, exhibiting erratic, spontaneous beating regulated by sensory inputs and sudden, quiet pauses between burst responses to punctuate stimulus.Furthermore, the network's Golgi cell interaction offers insight into how these neurons may control the spatiotemporal arrangement of cerebellar activity.Thus, the idea that Golgi cells play a crucial role in controlling the activity of the granular layer network, which has significant implications for cerebellar computing, is beginning to take shape.This is primarily because Golgi cells corelease GABA and glycine at each individual bouton, which is a result of cell-type-specific postsynaptic receptor expression and/or trafficking to the synapse.[19] The basal level of GABA produces a postsynaptic leak conductance by tonically activating alpha 6-containing GABA-A receptors on the granule cell.At high mossy firing frequency (10 Hz) there is no effect of GABA acting on presynaptic GABA-B receptors on evoked EPSCs.Moreover, such compound motions depend on a synaptic integration that is generated from granule cell NMDA receptor activation and GABA-mediated inhibition.The fundamental questions of whether dendritic processing underlies the theory-predicted spike-timing dependent plasticity (STDP) and how synaptic inputs govern the generation of Golgi cell spikes remain unanswered.[22] Making a forecast regarding the potential interconnections between these many active features is challenging and necessitates a thorough computational examination of synaptic integration and the neuron's electrogenic architecture.[12] Golgi type II dendrites have approximately symmetrical synaptic connections and have pale, asymmetric, and frequently massive profiles that contain huge pleomorphic vesicles.Afferent axons descending from the auditory cortex and ascending from the posterior colliculus form synaptic connections with both kinds of neurons.Golgi type II cells, being excitatory interneurons, have the ability to produce gradual or continuous response patterns that have the tendency to extend specific signal trains.
Excitatory synapsesinhibitory synapsesMossy fiberDeep cerebellar nucleiInferior oliveClimbing fiberGranule cellParallel fiberPurkinje cellStellate cellBasket cellcerebellumNeuroLexAnatomical terms of neuroanatomyneuroscienceinhibitoryinterneuronsdendritegranule cellsunipolar brush cellsmossy fibresparallel fibersmossy fibreglomerulusdendritesneurongrey mattercentral nervous systemCamillo GolgiGolgi stainSantiago Ramón y CajalList of distinct cell types in the adult human bodyBibcodeWayback MachineNeuroscience Information FrameworkAnatomyAnterior lobePosterior lobeHorizontal fissureFlocculonodular lobeFlocculusNodulePrimary fissureVermisCentral lobuleCulmenLingulaFoliumVallecula of cerebellumHemisphereAlar central lobuleBiventer lobuleCerebellar tonsilDentateinterposedEmboliformGloboseFastigialCerebellar cortexFañanas cellUnipolar brush cellMossy fibersWhite matterArbor vitaePedunclesInferiorDorsal spinocerebellar tractOlivocerebellar tractCuneocerebellar tractJuxtarestiform bodyVestibulocerebellar tractTrigeminocerebellar fibersMiddlePontocerebellar fibersSuperiorVentral spinocerebellar tractDentatothalamic tractNervous tissueProjection fibersAssociation fiberCommissural fiberLemniscusNerve tractDecussationNeuropilMeningesNeuronalPyramidalPurkinjeGranuleVon EconomoMedium spinyInterneuronAstrocyteEpendymal cellsTanycyteOligodendrocyte progenitor cellOligodendrocyteMicrogliaGanglionRamus communicansAutonomic ganglionPreganglionic nerve fibersPostganglionic nerve fibersNerve fascicleFuniculusConnective tissuesEpineuriumPerineuriumEndoneuriumNeurogliaMyelinationSchwann cellNeurilemmaMyelin incisureNode of RanvierInternodal segmentSatellite glial cellNeuronsnerve fibersAxon hillockTelodendronAxon terminalsAxoplasmAxolemmaNeurofibril/neurofilamentNissl bodyDendritic spineApical dendriteBasal dendriteBipolarUnipolarPseudounipolarMultipolarRenshawAfferent nerve fiberSensory neuronIa or AαIb or Golgi or AαII or Aβ and AγIII or Aδ or fast painIV or C or slow painEfferent nerve fiberMotor neuronUpper motor neuronLower motor neuronα motorneuronβ motorneuronγ motorneuronSynapseElectrical synapseGap junctionChemical synapseSynaptic vesicleActive zonePostsynaptic densityAutapseRibbon synapseNeuromuscular junctionSensory receptorsMeissner's corpuscleMerkel nerve endingPacinian corpuscleRuffini endingMuscle spindleFree nerve endingNociceptorOlfactory receptor neuronPhotoreceptor cellHair cellTaste receptor