Unipolar brush cell
The brush dendrioles emit numerous, thin evaginations called filopodia, unique to UBCs.[5] They work together with vestibular fibres to integrate signals involving the orientation of the head that modulates reflex behaviour.[6] UBCs function to amplify inputs from the vestibular ganglia and nuclei by spreading and prolonging excitation within the granular layer.In mammals, UBCs show an uneven distribution within the granule cell domains of the hindbrain, being the most dense in the vermis, part of the flocculus/paraflocculus complex, and layers 2–4 of the dorsal cochlear nucleus.[5] UBCs situated in cerebellar lobule VII are affected in some cases of Pick's disease, where they develop cytoskeletal anomalies and are recognized by antibodies to abnormally hyperphosphorylated tau proteins.