2-Methoxyestrone
2-Methoxyestrone (2-ME1) is an endogenous, naturally occurring methoxylated catechol estrogen and metabolite of estrone that is formed by catechol O-methyltransferase via the intermediate 2-hydroxyestrone.[1][2][3] Unlike estrone but similarly to 2-hydroxyestrone and 2-methoxyestradiol, 2-methoxyestrone has very low affinity for the estrogen receptor and lacks significant estrogenic activity.[4]This article about a steroid is a stub.You can help Wikipedia by expanding it.
IUPAC nameCAS NumberChEMBLChemSpiderECHA InfoCardPubChemCompTox DashboardSMILESChemical formulaMolar massstandard stateendogenousnaturally occurringmethoxylatedcatechol estrogenmetaboliteestronecatechol O-methyltransferaseintermediate2-hydroxyestrone2-methoxyestradiolaffinityestrogen receptorEstrogenUterine weightUterotrophyEstradiol (E2)Estrone (E1)Estriol (E3)Estetrol (E4)17α-Estradiol2-Hydroxyestradiol4-Hydroxyestradiol4-Methoxyestradiol4-Fluoroestradiol4-Hydroxyestrone4-Methoxyestrone16α-Hydroxyestrone2-Hydroxyestriol2-MethoxyestriolRelative binding affinityestrogen receptorsuterinecytosolovariectomizedsubcutaneously implantedosmotic pumpsLuteinizing hormoneSyntheticsteroidsPrecursorsCholesterol22R-Hydroxycholesterol20α,22R-DihydroxycholesterolPregnenolone17α-Hydroxypregnenolone21-HydroxypregnenoloneCorticosteroidsGlucocorticoids3α,5α-Tetrahydrocorticosterone5α-Dihydrocorticosterone11-Deoxycorticosterone11-Deoxycortisol11-Ketoprogesterone21-Deoxycortisol21-DeoxycortisoneCorticosteroneCortisolCortisone17α-HydroxyprogesteroneProgesterone5α-DihydrocortisolMineralocorticoids5α-Dihydroaldosterone11-Dehydrocorticosterone (11-oxocorticosterone, 17-deoxycortisone)11β-Hydroxyprogesterone (21-deoxycorticosterone)18-Hydroxy-11-deoxycorticosterone18-HydroxycorticosteroneAldosteroneSex steroidsAndrogens11-Ketodihydrotestosterone11-Ketotestosterone7β-Hydroxyepiandrosterone11β-HydroxyandrostenedioneAdrenosterone (11-ketoandrostenedione)AndrostenediolAndrostenedioneAndrosteroneDehydroandrosteroneDHEA sulfateDihydrotestosteroneEpiandrosteroneEpitestosterone16α-Hydroxyandrostenedione16α-Hydroxy-DHEA16α-Hydroxy-DHEA sulfateTestosterone3α-Androstanediol3α-Androstanediol glucuronide3β-Androstanediol5β-Dihydrotestosterone3α-Etiocholanediol3β-EtiocholanediolAndrostenediol sulfateAndrostenetriolAndrosterone glucuronideAndrosterone sulfateEtiocholanedioneEtiocholanoloneEtiocholanolone glucuronideEpietiocholanoloneTestosterone glucuronideTestosterone sulfateEstrogensEstetrolEstradiolEstriol16β-Epiestriol (16β-hydroxyestradiol)17α-Epiestriol (16α-hydroxy-17α-estradiol)16β,17α-Epiestriol (16β-hydroxy-17α-estradiol)4-Hydroxyestriol16β-Hydroxyestrone16-Ketoestradiol16-Ketoestrone27-Hydroxycholesterol