Historically, philosophers of physics have engaged with questions such as the nature of space, time, matter and the laws that govern their interactions, as well as the epistemological and ontological basis of the theories used by practicing physicists.Einstein's general relativity as well as the redshift of the light from receding distant galaxies indicate that the entire Universe and possibly space-time itself began about 13.8 billion years ago in the Big Bang.The uncertainty principle is a mathematical relation asserting an upper limit to the accuracy of the simultaneous measurement of any pair of conjugate variables, e.g. position and momentum.Bell's theorem is a term encompassing a number of closely related results in physics, all of which determine that quantum mechanics is incompatible with local hidden-variable theories given some basic assumptions about the nature of measurement."[6] The term is broadly applied to a number of different derivations, the first of which was introduced by Bell in a 1964 paper titled "On the Einstein Podolsky Rosen Paradox".Bell's paper was a response to a 1935 thought experiment that Albert Einstein, Boris Podolsky and Nathan Rosen proposed, arguing that quantum physics is an "incomplete" theory.Consequently, the only way that hidden variables could explain the predictions of quantum physics is if they are "nonlocal", which is to say that somehow the two particles can carry non-classical correlations no matter how widely they ever become separated.In March 1927, working in Niels Bohr's institute, Werner Heisenberg formulated the principle of uncertainty thereby laying the foundation of what became known as the Copenhagen interpretation of quantum mechanics.[15][16] Features common to Copenhagen-type interpretations include the idea that quantum mechanics is intrinsically indeterministic, with probabilities calculated using the Born rule, and the principle of complementarity, which states that objects have certain pairs of complementary properties that cannot all be observed or measured simultaneously.It denies wavefunction collapse, and claims that superposition states should be interpreted literally as describing the reality of many-worlds where objects are located, and not simply indicating the indeterminacy of those variables.Philosophers have sought to understand how the asymmetric behavior of macroscopic systems, such as the tendency of heat to flow from hot to cold bodies, can be reconciled with the time-symmetric laws governing the motion of individual particles.The epistemic interpretation, also known as the subjective or Bayesian view, holds that probabilities in statistical mechanics are a measure of our ignorance about the exact state of a system.According to this view, we resort to probabilistic descriptions only due to the practical impossibility of knowing the precise properties of all its micro-constituents, like the positions and momenta of particles.In contrast, the ontic interpretation, also called the objective or frequentist view, asserts that probabilities in statistical mechanics are real, physical properties of the system itself.[32] Until the discovery of subatomic particles and the quantum mechanics governing them, many of Leibniz's speculative ideas about aspects of nature not reducible to statics and dynamics made little sense.