Mimotope

When the term mimotope was first coined by Mario Geysen in 1986,[1] it was used to describe peptides mimicking epitopes.As the mimic of binding site, mimotope analysis has been widely used in mapping epitopes,[2] identifying drug target and inferring protein interaction networks.Besides the core data on panning experiments and their results, broad background information on target, template, library and structure is included.An accompanied benchmark has also been compiled for bioinformaticians to develop and evaluate their new models, algorithms and programs.In addition, the MimoDB database provides tools for simple and advanced searches, structure visualization, BLAST and alignment view on the fly.
peptideepitopeantibodyphage displaybiopanningVaccinesaptamersMimoDBBibcodeJensen-Jarolim, ELymphocyticadaptive immune systemcomplementAntigenSuperantigenAllergenAntigenic variationHaptenLinearConformationalAntigen presentationprofessional APCsDendritic cellMacrophageB cellImmunogenMonoclonal antibodiesPolyclonal antibodiesAutoantibodyMicroantibodyPolyclonal B cell responseAllotypeIsotypeIdiotypeImmune complexParatopeImmunityAutoimmunityAlloimmunityAllergyHypersensitivityInflammationCross-reactivityCo-stimulationToleranceCentralPeripheralClonal anergyClonal deletionTolerance in pregnancyImmunodeficiencyImmune privilegeImmunogeneticsAffinity maturationSomatic hypermutationClonal selectionV(D)J recombinationJunctional diversityImmunoglobulin class switchingLymphocytesCellularT cellHumoralNK cellCytokinesOpsoninCytolysinimmunology