Basophil
[2] They also produce compounds that coordinate immune responses, including histamine and serotonin that induce inflammation, and heparin that prevents blood clotting,[3] although there are less than that found in mast cell granules.However, they arise from different branches of hematopoiesis, and mast cells usually do not circulate in the blood stream, but instead are located in connective tissue.Basophils have protein receptors on their cell surface that bind IgE, an immunoglobulin involved in macroparasite defense and allergy.It is the bound IgE antibody that confers a selective response of these cells to environmental substances (e.g., pollen proteins or helminth antigens).Recent studies in mice suggest that basophils may also regulate the behavior of T cells and mediate the magnitude of the secondary immune response.When activated, basophils degranulate to release histamine, proteoglycans (e.g. heparin and chondroitin), and proteolytic enzymes (e.g. elastase and lysophospholipase).[17] Basophils are easily isolated from venous blood and present good "indicator cells" of an IgE-mediated allergic response based on the upregulation of activation markers such as CD63 and/or CD203c upon suspect allergen stimulation.
basophil cellSystemImmune systemAnatomical terms of microanatomywhite blood cellgranulocytewhite blood cellsanaphylaxisasthmaatopic dermatitishay feverhistamineserotoninheparinblood clottingmast cellconnective tissuePaul Ehrlichstainingcytoplasmiccell nucleusmicroscopehematopoiesisReference ranges for blood testsinflammatoryallergiceosinophilsimmunoglobulinallergypollenhelminthT cellsHerpesvirus-6homologbone marrowdegranulateproteoglycanschondroitinproteolytic enzymeselastaselysophospholipaseleukotrienescytokinescytokineinterleukin-4flow cytometrycontrast mediumBasopeniaurticariaBasophilialeukemialymphomaFcεRIintegrinCD107aectoenzymeallergen immunotherapycombining formsDiamine oxidaseEosinophilFood intoleranceHistamine intoleranceHistamine N-methyltransferaseList of distinct cell types in the adult human bodyJaneway CA Jr.plasmaMyelopoiesisCFU-GEMMCFU-GMGranulopoiesisMyeloblastPromyelocyteMyelocyteMetamyelocyteBand cellMonocytopoiesisMonoblastPromonocyteThrombopoiesisMegakaryoblastPromegakaryocyteErythropoiesisProerythroblastNormoblastReticulocyteExtramedullary hematopoiesisMyeloid tissueGranulocytesNeutrophilCFU-BasoCFU-EosCFU-MastMonocytesMacrophagesHistiocytesKupffer cellsAlveolar macrophageMicrogliaOsteoclastsEpithelioid cellsgiant cellsLanghans giant cellsForeign-body giant cellTouton giant cellsDendritic cellsLangerhans cellCFU-DLPlateletsCFU-MegMegakaryocyteRed blood cellsNucleated red blood cellLeukocyte extravasationPhagocytosisIntrinsic immunityMegakaryocyte–erythroid progenitor cellMyelomonocytePhagocyteHematopoietic systemHematopoietic stem cellLymphocyticadaptive immune systemcomplementAntigenSuperantigenAllergen