Andarine
Andarine (developmental code names GTx-007, S-4) is a selective androgen receptor modulator (SARM) which was developed by GTX, Inc for the treatment of conditions such as muscle wasting, osteoporosis, and benign prostatic hyperplasia (BPH),[1] using the nonsteroidal antiandrogen bicalutamide as a lead compound.[2] Development of andarine for all indications has been discontinued, in favor of the structurally related and improved compound enobosarm (ostarine; GTx-024; S-22).In castrated male rats, this dose restored only 32.5% prostate weight, but 101% levator ani muscle weight [4] This suggests that andarine is able to competitively block binding of dihydrotestosterone to its receptor targets in the prostate gland, but its partial agonist actions at the androgen receptor prevent the side effects associated with the antiandrogens traditionally used for treatment of BPH.[9][10] Three phase 1 trials (1a, 1b, 1c) were completed with the drug involving 86 healthy male and female volunteers.[10] However, development of andarine was discontinued, reportedly due to findings of visual disturbances in clinical studies.