77-LH-28-1
77-LH-28-1 is a selective agonist of muscarinic acetylcholine receptor subtype 1 (M1) discovered in 2008.It is an allosteric agonist, exhibiting over 100-fold specificity for M1 over other muscarinic receptor subtypes.77-LH-28-1 penetrates the brain by crossing the blood–brain barrier and is therefore a useful pharmacological tool with cognition enhancing effects.[1] It has been used as a lead compound for discovery of other M1 agonists, and a crystal structure of the bound complex between 77-LH-28-1 and the M1 receptor has been published.[2] This drug article relating to the nervous system is a stub.