Dibenzepin

Dibenzepin, sold under the brand name Noveril among others, is a tricyclic antidepressant (TCA) used widely throughout Europe for the treatment of depression.As TCAs have a relatively narrow therapeutic index, the likelihood of overdose (both accidental and intentional) is fairly high and should be considered carefully by the prescribing physician prior to patient use.Symptoms of overdose are similar to those of other TCAs, with cardiac toxicity (due to inhibition of sodium and calcium channels) generally occurring before the threshold for serotonin syndrome is reached.Dibenzepin acts as a selective norepinephrine reuptake inhibitor (NRI), with similar potency to that of imipramine.[3] It has also been marketed under a number of other brand names, including Ansiopax, Deprex, Ecatril, Neodit, and Victoril.
Drugs.comRoutes ofadministrationATC codeN06AA08Legal statusPharmacokineticBioavailabilityProtein bindingMetabolismHepaticElimination half-lifeExcretionIUPAC nameCAS NumberChemSpiderChEMBLCompTox DashboardFormulaMolar massSMILEStricyclic antidepressantEuropedepressionimipramineside effectsmajor depressive disorderneuropathic painTricyclic antidepressant overdoseoverdoseserotonin syndromePharmacology of antidepressants5-HT1A5-HT2A5-HT2Cselectivenorepinephrine reuptake inhibitorpotencyantihistamineserotonindopaminereuptakeantiadrenergicantiserotonergicantidopaminergicanticholinergicplasma protein bindingSwitzerlandWest GermanyFranceUnited KingdomPortugalIsraelAnvisaDiário Oficial da UniãoRoth BLAntidepressantsreuptake inhibitorsreceptor modulatorsCitalopramEscitalopramFluoxetineFluvoxamineIndalpineParoxetineSertralineZimelidineDesvenlafaxineDuloxetineLevomilnacipranMilnacipranTofenacinVenlafaxineAtomoxetineReboxetineViloxazineAmineptineBupropionNomifensineNaSSAsMianserinMirtazapineSetiptilineEtoperidoneNefazodoneTrazodoneVilazodoneVortioxetineAgomelatineAmisulprideDextromethorphan/bupropionEsketamineEtryptamineGepironeIndeloxazineFlupentixolKetamineMedifoxamineMetryptamineOxaflozanePivagabineTandospironeTeniloxazineTianeptineTricyclictetracyclic antidepressantsAmitriptylineAmitriptylinoxideAmoxapineButriptylineClomipramineDemexiptilineDesipramineDimetacrineDosulepinDoxepinImipraminoxideIprindoleLofepramineMelitracenMetapramineNitroxazepineNortriptylineNoxiptilineOpipramolPipofezinePropizepineProtriptylineQuinupramineTrimipramineMaprotilineTiazesimMonoamine oxidase inhibitorsBenmoxinIproclozideIproniazidIsocarboxazidIsoniazidLinezolidMebanazineNialamideOctamoxinPhenelzinePheniprazinePhenoxypropazinePivhydrazineSafrazineTedizolidTranylcypromineCaroxazoneBifemelaneEprobemideMetralindoleMinaprineMoclobemidePirlindoleTetrindoleToloxatoneSelegilineAdjunctive therapiesAtypical antipsychoticsaripiprazolebrexpiprazolelurasidoneolanzapinequetiapinerisperidoneBuspironeLithiumlithium carbonatelithium citrateThyroid hormonestriiodothyroninelevothyroxineAdemetionine (SAMe)GABAkineneurosteroidsbrexanolonezuranoloneHypericum perforatum (St. John's Wort)Oxitriptan (5-HTP)Rubidium chloride (RbCl)TryptophanWHO-EMWithdrawnClinical trialsPharmacodynamicsHistamine receptormodulators2-PyridylethylamineBetahistineHistamineL-HistidineUR-AK494-MethyldiphenhydramineAlimemazineAntazolineAzatadineBamipineBenzatropine (benztropine)BepotastineBromazineBrompheniramineBuclizineCaptodiameCarbinoxamineChlorcyclizineChloropyramineChlorothenChlorphenamineChlorphenoxamineCinnarizineClemastineClobenzepamClocinizineCloperastineCyclizineCyproheptadineDacemazineDeptropineDexbrompheniramineDexchlorpheniramineDimenhydrinateDimetindeneDiphenhydramineDiphenylpyralineDoxylamineEmbramineEtodroxizineEtybenzatropine (ethylbenztropine)EtymemazineFenethazineFlunarizineHistapyrrodineHomochlorcyclizineHydroxyethylpromethazineHydroxyzineIsopromethazineIsothipendylMeclozineMedrylamineMepyramine (pyrilamine)MequitazineMethafuryleneMethapyrileneMethdilazineMoxastineOrphenadrineOxatomideOxomemazinePerlapinePhenindaminePheniraminePhenyltoloxaminePimethixenePiperoxanPipoxizinePromethazinePropiomazinePyrrobutamineTalastineThenalidineThenyldiamineThiazinamiumThonzylamineTolpropamineTripelennamineTriprolidineAcrivastineAstemizoleAzelastineBilastineCetirizineClemizoleClobenztropineDesloratadineEbastineEmedastineEpinastineFexofenadineKetotifenLatrepirdineLevocabastineLevocetirizineLoratadineMebhydrolinMizolastineOlopatadineQuifenadine (phencarol)RupatadineSetastineTerfenadineasenapinebrilaroxazineclozapineiloperidonepaliperidoneziprasidonezotepinePhenylpiperazinehydroxynefazodonetriazoledioneloxapineoxaprotilineTricyclic antidepressantsdosulepin (dothiepin)Typical antipsychoticschlorpromazineflupenthixolfluphenazineperphenazineprochlorperazinethioridazinethiothixeneNapactadineAmthamineBetazoleDimapritImpromidineBurimamideCimetidineEbrotidineFamotidineLafutidineLavoltidine (loxtidine)LupitidineMetiamideNiperotidineNizatidineOxmetidineRanitidineRoxatidineSufotidineZolantidineα-MethylhistamineCipralisantImetitImmepipImmethridineMethimepipProxyfanA-349821A-423579ABT-239CiproxifanClobenpropitConessineEnerisantGSK-189254ImpentamineIodophenpropitJNJ-5207852NNC 38-1049PF-03654746PitolisantSCH-79687ThioperamideVUF-56814-MethylhistamineOUP-16VUF-8430JNJ-7777120ToreforantVUF-6002Monoamine reuptake inhibitorsDBL-583GBR-12783GBR-12935GBR-13069GBR-13098JJC8-088Vanoxerine4-FluoropethidineBenocyclidine (BTCP)DesoxypipradrolDexmethylphenidateDifemetorexEthylphenidateHDMP-28MethylphenidatePethidine (meperidine)PhencyclidinePipradrolSerdexmethylphenidateTenocyclidineDiphenylprolinolNaphyroneProlintanePyrovaleroneAltropaneBrasofensineCocaineDichloropaneDifluoropineEtybenzatropine (ethybenztropine)FE-β-CPPITFP-β-CPPITIoflupane (123I)RTI-55RTI-112RTI-113RTI-121RTI-126RTI-150RTI-177RTI-229RTI-336TesofensineTroparilTropoxaneAdrafinilAmifitadineArmodafinilAmfonelic acidAnsofaxineBTS 74,398Chaenomeles speciosaCiclazindolDasotralineDesmethylsertralineDesmethylsibutramine (BTS-54354)DiclofensineDidesmethylsibutramine (BTS-54505)DimethocaineDizocilpine (MK-801)DOV-102,677DOV-216,303EfavirenzEphenidineEXP-561FencamfaminFezolamineFluorenolGYKI-52895HydroxybupropionIndatralineLefetamineLevophacetoperaneLiafensineLR-5182ManifaxineMazindolMesocarbMetaphitMIN-117 (WF-516)ModafinilNefopamNS-2359O-2172Oroxylin APerafensinePridefineRadafaxineRimcazoleSibutramineSolriamfetolTametralineTedatioxetineThreohydrobupropionAmedalinAlseroxylonDaledalinEdivoxetineEsreboxetineLortalamineNisoxetineTalopramTalsupramTandamineFencamineAtomoxetine (tomoxetine)CP-39,332EclanamineMcN5652N-Methyl-PPPA3,3-DiphenylcyclobutanamineBicifadineCentanafadineDOV-102677DOV-216303HP-505JNJ-7925476JZ-IV-10PRC200TropanesCianopramineAntihistaminesAntipsychoticsArylcyclohexylaminesDopexamineGinkgo bilobaOpioidsdesmetramadolmethadonetapentadoltramadollevorphanol6-NitroquipazineAlaproclateCentpropazineCericlamineDapoxetineDesmethylcitalopramDidesmethylcitalopramFemoxetineIfoxetineNorfluoxetineOmiloxetinePanuraminePIM-35PirandamineRTI-353SeproxetineLitoxetineLubazodoneLY-393558QuipazineSB-649915TGBA01ADCyanodothiepin3-MeO-PCPmethoxetamineCyclobenzaprineDelucemineDextromethorphanDextrorphanHypidoneMesembrineMifepristoneN-Me-5-HTdextropropoxypheneRoxindoleAmiodaroneAmphetaminesamphetaminemethamphetamineBietaserpineDeserpidineDeutetrabenazineDihydrotetrabenazineIbogaineKetanserinLobelineReserpineRose bengalTetrabenazineValbenazineVanoxerine (GBR-12909)LuteolinSoRI-9804SoRI-20041TricyclicsClassesAcridineAnthraceneDibenzazepineDibenzocyclohepteneDibenzothiazepineDibenzothiepinDibenzoxazepineDibenzoxepinPhenothiazinePyridazinobenzoxazinePyridinobenzodiazepineThioxantheneAmezepineAptazapineAzepindoleBatelapineCidoxepinCotriptylineDepramine (balipramine)Desipramine (desmethylimipramine)DesmethylclomipramineEnprazepineFluotracenHepzidineHomopipramolIntriptylineKetipramineLitracenLosindoleMariptilineMezepineMonometacrineNordoxepinNorthiaden (nordosulepin)Nortriptyline (noramitriptyline)OctriptylineTampramineTienopramineBisulepinPirolateAcetophenazineButaclamolButaperazineCarfenazine (carphenazine)CarpipramineChlorprothixeneCiclindoleClocapramineClomacranClorotepineClotiapineFlucindoleFlumezapineGevotrolineLevomepromazine/MethotrimeprazineMesoridazineMetiapineMetitepineMosapramineNaranolOxyprothepinPerathiepinPerazinePericiazinePinoxepinPiperacetazinePipotiazinePiquindonePromazineProthipendylSulforidazineTenilapineThiethylperazineThiopropazateTrifluoperazineTriflupromazineZuclopenthixolAnticonvulsantsCarbamazepineDizocilpineEslicarbazepineEslicarbazepine acetateEtazepineLicarbazepineOxcarbazepineOxitriptylineAnticholinergicsPirenzepineProfenamineTelenzepineTripitramineTropatepineAdosopineAtiprosinBenzoctamineBotiacrineCarvedilolMethylene blueMonatepilOxetoronePipazethatePitrazepinPizotifenSerazapineTipindole