Timeline of aging research

The species limit of human life is estimated by scientists at 125–127 years,[5][6] and even in the most ideal conditions a person will not live longer due to aging of the body.Some scientists believe that, even if medicine learns how to treat all major diseases, that will increase the average lifespan of people in developed countries by only about 10 years.Searches of various equivalents of the elixir of youth happened yet in ancient times: people hoped to find a miraculous remedy in faraway territories, tried to use magic and alchemy.From the end of the 19th century, systematic scientific and technical studies began on the processes of slowing down aging and possible rejuvenation.In many spheres of life, there were ideas that were radical-bold, but not always intelligent, ethical and moral from the point of view of modern knowledge, foundations and norms.
Past and projected age of the human world population through time as of 2021 [ 151 ]
Healthspan-lifespan gap (LHG) [ 151 ]
Healthspan extension relies on the unison of social, clinical and scientific programs or domains of work. [ 151 ]
Expected life years gained for 20-year-olds in the U.S. who change from a typical Western diet to an, according to an integrative study, "optimized diet" (changes indicated on the left in gram) [ 166 ]
Results of the first longevity caloric restriction (CR) trial, CALERIE
A global consortium identifies changes in methylation levels that occur with age across mammals. [ 225 ]
senescenceresearch and developmentrejuvenationHippocratesAphorismsAristotleOn youth and old agePersianIbn Sinaaverage lifespanTerentiaJeanne CalmentsupercentenariansLeonard Hayflicklife expectancyMonacobiomedical technologiesQin Shi Huangelixir of youthpills of immortalityWu of HanCaesar Augustuseternal youthalchemyphilosopher's stoneiatrochemistryParacelsusJan Baptist van HelmontFranciscus SylviuspharmacyFountain of YouthJuan Ponce de LeónVenetianLuigi CornaroGompertz–Makeham law of mortalityAlfred Russel WallaceAugust WeismannCharles-Édouard Brown-Séquardhormone replacement therapyIlya MechnikovyogurtbacteriaprobioticNobel PrizeLeo L. StanleyEugen SteinachvasectomysexologyAlexis CarrelanastomosisasepsisMathieu JaboulayEmerich UllmannJacques LoebJohn NorthropPorfiry Bakhmetievtissue engineeringcardiopulmonary bypassdialysisorgan donationcryobiologyLeo Leonidas StanleySerge/Samuel Voronoffsuspensionallotransplantationxenotransplantationsex hormonesestrogentestosteroneHeart of a DogThe Adventure of the Creeping ManIrving BerlinAlexander BogdanovInstitute for Blood TransfusionPaul NiehansWinston ChurchillCharles de GaullePope Pius XIIcell therapyregenerative medicineKishinevKingdom of RomaniaDimu KotsovskyRomanianClive McCaylabilepathophysiologistAlexander Bogomoletsantireticular cytotoxic serumLeipzigBritish Society for Research on AgeingVladimir KorenchevskyWorld War IIGerontological Society of AmericaInternational Association of Gerontology and GeriatricsPeter Medawarmutation accumulation theoryVladimir DilmanDenham Harmanfree-radical theory of agingRebeca GerschmanGeorge Williamsantagonistic pleiotropy hypothesisGioacchino FaillaDNA damageLeo SzilardDNA damage theory of agingsomatic cellsHayflick limitRoy WalfordNational Institute on AgingNational Archive of Computerized Data on AgingThomas Kirkwooddisposable soma theorytelomeraseribonucleoproteintelomeresElizabeth BlackburnCarol GreiderAlexey OlovnikovJack SzostakDemidov PrizeReliability theory of aging and longevityGerontology Research GroupCynthia KenyonC. eleganssenescent cellsChristian MortensennormalBuck Institute for Research on AgingSierra SciencesWilliam H. Andrewsgenetic limitsmeasuringhealthy lifestylepreventive medicinenematodesMethuselah FoundationAubrey de GreyDavid GobelStrategies for engineered negligible senescenceAMP-Kinaselongevity escape velocityRobert WilsondatabaseShinya YamanakaJohn GurdoninsulinEnding Agingpharmacological agentmetforminMax Planck Institute for Biology of AgeingrapamycinSENS Research FoundationScience Party of AustraliaU.S. Transhumanist PartyParty for Rejuvenation ResearchHarvard UniversityDana–Farber Cancer InstituteSirtuin 6Epigenetic clockSteve HorvathJiroemon KimuraSirtuin 1CalicoArthur Levinsonpharmacological activationDog Aging ProjectUniversity of Washingtonas a diseasemitochondriastem cellsYamanakareprogrammingpolymorphismAgeX TherapeuticsJames AllisonTasuku Honjoerrors in DNAWorld Health OrganizationICD-11Caenorhabditis elegansMayo Clinicsenolyticscombininglithiumtrametinibfruit fliessingle-cell RNA analysiscytotoxic CD4 T-cellsbiological datagenomic lociintrinsically influencehealthspanlifespanlongevitygenome-wide significancecardiovascular diseasebenefits of regular exercise for their brainsgenetically engineercellular agingmyeloid cellsmaladaptiveinflammationbrain-ageingreversedrandomized clinical trialcombination therapyphytonutrientprobioticsbiomarkerDNA methylomeinflammatory agecytokinegut microbiomesbile acidscentenarianstransplantationfecal microbiotarejuvenatesbrainscosts of treatments[c]hronic diseases of agingquality of lifewellbeingscientific reviewdietary restrictionintermittent fastingcaloric restrictionincreasing health- and lifespanprecisioncircadian-regulatedautophagyDrosophilaflavonoidProcyanidin C1grape seed extracthealth- and lifespanAltos Labsmeta-analyseslife extensionof different food groupsCALERIEPLA2G7reviewnutrition researchpreventive healthcareextended life spansC57BL/6Jcognitive agingsustainabilityhealthinesscouponscohort studydietaryflavonolskaempferolquercetincognitive abilities with older agepaywalleddaily energy consumptionultra-processed foodscognitive declinesupplementsglycinecan extend lifespanBiomedical gerontologistsDasatinibhuman trialT. dohrniicellular rejuvenationiPSC reprogrammingreverseYamanaka factorsin vitrotranscriptomeepigenomefibroblastcomparison of the newly presented genomesbiologically immortalDNA replicationrepairAxolotlsleprosyarmadilloscerebrospinal fluidaged brainsproduce blood cellstheory of ageinghealthy agingblood cells'a subset of cellsfibrosisheart risksimmuneT cellsentorhinal cortexover age 80sphingolipidsceramidemyriocinmuscle lossroundwormwith lightmitochondrialmembrane potentialhallmarks of agingaging clocksdeep learningbrain ageneuroanatomicalDNA methylationcognitive functioningBryan JohnsonProject Blueprintself-experimentationsand organ measurementsmaximally reversemedia attentionbiohackerschest radiographsDavid SinclairDNA breaksepigeneticpreprintHarvard Medical Schooltransferrednaked mole-ratsUniversity of EdinburghMassachusetts Institute of Technologyartificial intelligencetaurineage reversalfibroblastsα-klothoenhancedcognitionretroviruseshuman genomesneutralizing antibodiesColumbia UniversityhypermetabolismNew York Universitymelanocyteextends lifespanviromeUniversity of ColoradoCaMKIIplateletshealth- and life-extensionaging brainshematopoietic stem cellsimmune system agingImperial College LondonMRC London Institute of Medical SciencesDuke–NUS Medical Schoolinterleukin 11Stanford University2025 in scienceArchaeologySustainable energy researchComputingPaleontologySpaceflightDiscovered exoplanetsClimate changeLiteraturePhilosophyTimeline of cosmological theoriesList of open letters by academicsBiogerontologySenolyticResearch into centenariansList of causes of death by rateYears of potential life lostCRISPR gene editingregeneration in humansNeurobiological effects of physical exercisePublic healthhealth policyenvironmental policyconsumer protectionStambler IBibcodeCIA World FactbookWayback MachineCornaro LMetchnikoff EInternational Longevity AllianceThe Scientific MonthlyThe Journal of NutritionBogomolets AADilman VMEvolutionOlovnikov AMSkulachev WPSkulachev VPThe ScientistBBC News Onlinede Grey ADRobert Anton WilsonFuture LifeLive ScienceYamanaka SerratumMIT Technology ReviewThe GuardianQuartzKhaltourina DLifespan.ioMediumMDI Biological LaboratoryBig ThinkBaylor College of MedicineMax Planck SocietySalk InstituteNew ScientistNorthwestern UniversitybioRxivUniversity of Rochester Medical CenterThe New ArabBusiness WireDeutschlandfunk NovaOutline ofAnti-oxidantsAnti-aging movementBiohackingCalorie restrictionCryonicsCyborgExerciseFree-radical theoryGene therapyGerontologyGlycationIndefinite lifespanIndex of topics related to life extensionList of aging processesMind uploadingNanomedicineOrgan printingStem-cell therapyTranshumanist politicsTimeline of senescence researchBill AndrewsEric R. BravermanLaura DemingSaul KentRay KurzweilLiz ParrishDurk PearsonMark RothSandy ShawMichael D. West2045 InitiativeAlliance for Aging ResearchBuck InstituteBioVivaHuman LongevityImmortalist SocietyInsilico MedicineMPI for Biology of AgeingThe First ImmortalAgeing Research ReviewsAging CellExperimental GerontologyNeurobiology of AgingRejuvenation Research