Vobasine

[2] The two structurally related compounds, dregamine and tabernaemontanine, where its alkene (=CHCH3) sidechain was reduced to ethyl groups in two configurations, had their relationship confirmed in the 1970s.[3][4][5] Vobasine has been found in many plants of the dogbane (Apocynaceae) family including Tabernaemontana dichotoma.[6][7] As with other Indole alkaloids, the biosynthesis of vobasine starts from the amino acid tryptophan.[8] The synthesis of alkaloids with the same carbon skeleton as vobasine began in the 1960s[9] and has continued, with some work providing enantiospecific approaches to closely related compounds.[2] Plant metabolites have been of interest for their possible biological activity and alkaloids in particular are major subjects for ethnobotanical research.
Voacanga africana , a source of vobasine
IUPAC namePreferred IUPAC nameCAS NumberChemSpiderPubChemSMILESChemical formulaMolar massstandard statemonoterpeneindole alkaloidTabernaemontanaTabernaemontana divaricataVoacanga africanadregaminetabernaemontaninealkenereducedethyl groupsconfigurationsApocynaceaeTabernaemontana dichotomaIndole alkaloidsamino acidtryptophanstrictosidineenantiospecificgeneraVoacangaErvatamia hirtaTabernaemontana elegansmetabolitesbiological activityethnobotanicalhypotensiveErvaticineVoacristineBibcode