Properdin
1W0R, 1W0S519918636ENSG00000126759ENSMUSG00000001128P27918P11680NM_002621NM_001145252NM_008823NP_001138724NP_002612NP_032849Properdin is a protein that in humans is encoded by the CFP (complement factor properdin) gene.Native properdin occurs in head-to-tail dimers, trimers and tetramers in the fixed ratio 22:52:28.It plays a part in tissue inflammation as well as the engulfing of pathogens by phagocytes.The properdin promotes the association of C3b with Factor B and provides a focal point for the assembly of C3bBb on a surface.This branch of the complement system is activated by IgA immune complexes and bacterial endotoxins, polysaccharides, and cell walls, and results in producing anaphylatoxins, opsonins, chemotactic factors, and the membrane attack complex, all of which help fight pathogens.
AliasesHomoloGeneGeneCardsX chromosome (human)RNA expressionGene ontologyOrthologsEntrezEnsemblUniProtPubMedWikidataproteinglycoproteincomplement systeminnate immune systemC5-convertaseattack complexglobulinimmune responsestissueinflammationpathogensphagocytesvirusesFactor BC3-convertasesFactor Hantibodiesendotoxinspolysaccharidescell wallsanaphylatoxinsopsoninschemotactic factorsmembrane attack complexLouis PillemerCase Western Reserve UniversityProperdin deficiencyX-linked diseasemeningococcal diseaseWayback MachineMedical Subject HeadingsGlobular proteinsglobulinsAlpha globulinsserpinsAlpha 1-antichymotrypsinAlpha 1-antitrypsinAlpha 2-antiplasminAntithrombinHeparin cofactor IIcarrier proteinsTranscortinCeruloplasminRetinol binding proteinOrosomucoidalpha-2-MacroglobulinHaptoglobinBeta globulinsSex hormone-binding globulinTransferrinAngiostatinHemopexinBeta-2 microglobulinPlasminogenGamma globulinImmunoglobulinsFibronectinFetal fibronectinMacroglobulinMicroglobulinTranscobalaminEdestinBeta-lactoglobulinLactoferrinThyroglobulinAlpha-lactalbumin11S globulin familyAlbuminsEgg whiteConalbuminOvalbuminAvidinSerum albuminHuman serum albuminBovine serum albuminPrealbuminC-reactive proteinLactalbuminParvalbuminVitamin D-binding proteinExtracellular matrix protein 1Factor DC3-convertaseC1-inhibitorDecay-accelerating factorFactor IComplement receptorsAnaphylatoxinCytotoxicityimmune adherenceOpsonization