Alpha 2-antiplasmin
2R9Y534518816ENSG00000167711ENSG00000276838ENSMUSG00000038224P08697Q61247NM_000934NM_001165920NM_001165921NM_008878NP_000925NP_001159392NP_001159393NP_032904Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin.[5] Plasmin is an important enzyme that participates in fibrinolysis and degradation of various other proteins.As plasmin degrades blood clots, impaired inhibition of plasmin leads to a bleeding tendency, which was severe in the cases reported.In liver cirrhosis, there is decreased production of alpha 2-antiplasmin, leading to decreased inactivation of plasmin and an increase in fibrinolysis.This is associated with an increase risk of bleeding in liver disease.
AliasesHomoloGeneGeneCardsChromosome 17 (human)RNA expressionGene ontologyOrthologsEntrezEnsemblUniProtPubMedWikidataserine protease inhibitorplasminenzymefibrinolysisalpha-2-antiplasmin deficiencycirrhosisinteractNeutrophil elastaseSerpinThrombosis ResearchMEROPSMedical Subject HeadingsUCSC Genome BrowserCoagulation cascadeCoagulation factorsvon Willebrand factor (vWF)Platelet membrane glycoproteinsGlycoprotein Ib (GPIb)Glycoprotein IX (GP9)Glycoprotein IIb/IIIaGPIIIaGlycoprotein VI (GPVI)High-molecular-weight kininogen (HMWK)BradykininPrekallikreinKallikreinFactor XII (Hageman factor)Factor XIFactor IXFactor VIIIFactor III (tissue factor)Factor VIIFactor XFactor VProthrombin (factor II)Thrombin (factor IIa)Fibrinogen (factor I)Fibrin (factor Ia)Factor XIIIAnticoagulant factorsAntithrombin (inhibits FII, FIX, FX, FXI, FXII)Protein C (inhibits FV, FVIII)Protein S (cofactor for protein C)Protein Z (inhibits FX)Protein Z-related protease inhibitor (ZPI) (inhibits FX, FXI)Tissue factor pathway inhibitor (TFPI) (inhibits FIII)Fibrinolytic factorsPlasminogenTissue plasminogen activator (tPA)UrokinasePlasminogen activator inhibitor-1 (PAI-1)Plasminogen activator inhibitor-2 (PAI-2)α2-MacroglobulinThrombin-activatable fibrinolysis inhibitor (TAFI)Coagulation markersPlatelet activationPlatelet factor 4 (PF4)β-Thromboglobulin (β-TG)Thrombin generationProthrombin fragment 1+2 (F1+2)Thrombin–antithrombin complex (TAT)Activated protein C–protein C inhibitor (APC–PCI)Fibrin generationFibrinopeptide A (FpA)Fibrinopeptide B (FpB)Fibrin monomers (FM)Plasmin-α2-antiplasmin complex (PAP)D-Dimer (DD)SerpinsAlpha 1-antichymotrypsinAlpha 1-antitrypsinAntithrombinC1-inhibitorHeparin cofactor IIProtein C inhibitorPlasminogen activator inhibitor-1Plasminogen activator inhibitor-2Protein Z-related protease inhibitorSERPINA1SERPINA2SERPINA3SERPINA4SERPINA5SERPINA9SERPINA14SERPINB1SERPINB2SERPINB3SERPINB4SERPINB5SERPINB6SERPINB7SERPINB8SERPINB9SERPINB10SERPINB13SERPINC1SERPIND1SERPINE1SERPINE2SERPINF1SERPING1SERPINH1SERPINI1SERPINI2SCCA-1Heat shock protein 47MaspinOvalbuminTranscortinThyroxine-binding globulinAngiotensinogenGlobular proteinsglobulins