Polymeric immunoglobulin receptor
[11] Keith Mostov and colleagues found that secretory component was a proteolytic fragment of a transmembrane precursor, the pIgR, which led them to propose the currently accepted model[12] Polymeric immunoglobulin receptor is responsible for transcytosis of soluble dimeric IgA, pentameric IgM, and immune complexes from the basolateral to the apical mucosal epithelial cell surface.[7][10] The process of transporting polymeric immunoglobulins from the basolateral to apical side, known as transcytosis, is composed of several distinct steps.Transcytosis of IgA ICs from the formation sites represents an important mechanism of eliminating circulating antigens and minimizing their negative effects.Interaction of IL-1 and TNF-α with their receptors ultimately lead to transcriptional activation of PIGR gene due to nuclear translocation of NF-kB.[16] The level of pIgRs in the mucosal reproductive tract is highly dependent on the activity of sex hormones and correlates with estrous cycle phases.[6] IECs express a variety of Toll-like receptors (TLRs), activation of which ultimately leads to the pIgR upregulation during the infection.TLR4, like the majority of TLRs, transduce the signal though MyD88 adaptor and execute the function via NF-kB, which stimulates the expression of pIgR by binding to intron 1 of the gene.
AliasesHomoloGeneGeneCardsChromosome 1 (human)RNA expressionGene ontologyOrthologsEntrezEnsemblUniProtPubMedWikidatatransmembrane proteinFc receptortranscytosisimmunoglobulin Aimmunoglobulin Mimmune complexesintestinal epithelial cells (IECs)transmembrane proteinsproteolytic cleavagethe secretory componentPer BrandtzaegKeith Mostovdimeric IgAJ-chainclathrinendosomesmicrotubulesTNF-αIFN-γsex hormonesestrous cycleestrogenprogesteroneAndrogensglucocorticoidsProlactinJak-STAT pathwayToll-like receptorslipopolysaccharideBibcodeMedical Subject HeadingsTransmembrane receptorsimmunoglobulin superfamilyimmune receptorsFcεRIFcεRIIC-type lectinFcγRIFcγRIIFcγRIIINeonatalFcαRIFcα/μRB cellsCo-receptorT cellsLigandsMHC class IMHC class IICo-receptorsCytokine receptorKiller-cell IG-like receptorsKIR2DL1KIR2DL3KIR2DL4KIR2DS1KIR2DS4KIR3DL1KIR3DL2KIR3DL3Leukocyte IG-like receptorsLILRA1LILRA2LILRA3LILRA4LILRA5LILRB1LILRB2LILRB3LILRB4LILRB5United States National Library of Medicinepublic domain