Phosphoribosyl pyrophosphate
[1][2][3] The vitamins thiamine[4] and cobalamin,[5] and the amino acid tryptophan also contain fragments derived from PRPP.[6] It is formed from ribose 5-phosphate (R5P) by the enzyme ribose-phosphate diphosphokinase:[7] It plays a role in transferring phospho-ribose groups in several reactions, some of which are salvage pathways:[8] In de novo generation of purines, the enzyme amidophosphoribosyltransferase acts upon PRPP to create phosphoribosylamine.[2] The histidine biosynthesis pathway involves the reaction between PRPP and ATP, which activates the latter to ring cleavage.Carbon atoms from ribose in PRPP form the linear chain and part of the imidazole ring in histidine.[15][18][19] Increased levels of PRPP are characterized by the overproduction and accumulation of uric acid leading to hyperuricemia and hyperuricosuria.
Pooled Retirement Pension PlanIUPAC nameCAS NumberChemSpiderDrugBankPubChemCompTox DashboardSMILESChemical formulaMolar massstandard statepentose phosphatepurinenucleotidesinosine-5-monophosphatepyrimidinethiaminecobalamintryptophanribose 5-phosphateribose-phosphate diphosphokinasesalvage pathwaysadenine phosphoribosyltransferaseadeninehypoxanthine-guanine phosphoribosyltransferaseguaninehypoxanthinenicotinate phosphoribosyltransferasenicotinateorotate phosphoribosyltransferaseorotateuracil phosphoribosyltransferaseuracilxanthine phosphoribosyltransferasexanthinede novoamidophosphoribosyltransferasephosphoribosylaminehistidineanthranilic acidanthranilate phosphoribosyltransferaseuric acidhyperuricemiahyperuricosuriaLesch–Nyhan Syndromehypoxanthine guanine phosphoribosyl transferase5-Aminoimidazole ribotidePurine biosynthesisPyrimidine biosynthesisNucleotidemetabolic intermediatespurinemetabolismGlycineamide ribonucleotidePhosphoribosyl-N-formylglycineamide5′-Phosphoribosylformylglycinamidine5′-Phosphoribosyl-4-carboxy-5-aminoimidazolePhosphoribosylaminoimidazolesuccinocarboxamideAICA ribonucleotide5-Formamidoimidazole-4-carboxamide ribotideAdenylosuccinateXanthosine monophosphate5-HydroxyisouratepyrimidinemetabolismCarbamoyl aspartic acidCarbamoyl phosphate4,5-Dihydroorotic acidOrotic acidOrotidine 5'-monophosphateUridine monophosphateβ-AlanineDihydrouracil3-Ureidopropionic acidthymine3-Aminoisobutyric acidDihydrothymineβ-Ureidoisobutyric acid