Myrtle Creek is a city in Douglas County, Oregon, United States.A Myrtle Creek post office was established in 1854 with Lazarus Wright as postmaster.In 1862, Wright sold the land for a town site to John Hall, who laid out Myrtle Creek in 1865.[8] Myrtle Creek lies along Interstate 5 south of Roseburg and slightly north of Tri City and Canyonville in southern Douglas County.[10] According to the United States Census Bureau, the city has a total area of 2.51 square miles (6.50 km2), all of it land.[11] This region experiences warm (but not hot) and dry summers, with no average monthly temperatures above 71.6 °F (22.0 °C).