GDF5

This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues.The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues.These associations confirm that the gene product plays a role in skeletal development.[9][10][11] It also increases the survival of neurones that respond to the neurotransmitter dopamine, and is a potential therapeutic molecule associated with Parkinson's disease.You can help Wikipedia by expanding it.This molecular or cell biology article is a stub.
AliasesHomoloGeneGeneCardsChromosome 20 (human)RNA expressionGene ontologyOrthologsEntrezEnsemblUniProtPubMedWikidataproteinTGF-beta superfamilyacromesomelic dysplasiabrachydactylyosteochondrodysplasianeuronesneurotransmitterdopamineChondrodysplasia, Grebe typeBibcodeCell signalingTGFβ signaling pathwayTGF beta superfamily of ligandsTGF beta familyTGF-β1TGF-β2TGF-β3Activin and inhibinBone morphogenetic proteinsGrowth differentiation factorsMyostatin/GDF8Anti-müllerian hormoneTGF beta receptorsActivinfamilyActivin type 1 receptorsACVR1BACVR1CACVRL1BMPR1ABMPR1BActivin type 2 receptorsACVR2AACVR2BbetaglycanTransducersR-SMADI-SMADCerberusChordinDecorinFollistatinGremlinNogginCoreceptorsCriptoTGFβ receptor superfamilymodulatorsALK1 (ACVRL1)Avotermin2 (BMP9)AscrinvacumabDalanterceptALK2 (ACVR1A)AMH (MIS)Eptotermin alfaALK3 (BMPR1A)Dibotermin alfaALK4 (ACVR1B)11 (BMP11)Myostatin (GDF8)InhibinSB-431542ALK5 (TGFβR1)10 (BMP3B)FresolimumabLerdelimumabMetelimumabLY-2109761Galunisertib (LY-2157299)RepSox (E-616452, SJN-2511)ALK6 (BMPR1B)15 (GDF9B)6 (BMP13)7 (BMP12)ALK7 (ACVR1C)TGFβR2ACVR2A (ACVR2)SotaterceptOsteogenin (BMP3, BMP3A)AMHR2 (AMHR)TGFβR3 (β-glycan)Cerberus (CER1)DAN (PARN)Gremlin (Drm)Thrombospondin 1 (THBS1)StamulumabTRC105Endoglinchromosome 20molecularcell biology