[6][7] In 2018, Spaeny played several major film roles, starring in Steven S. DeKnight's science fiction monster adventure Pacific Rim Uprising, alongside John Boyega and Scott Eastwood; Drew Goddard's thriller Bad Times at the El Royale;[8][9][10] and the biographical dramas On the Basis of Sex and Vice.[12] In 2021, she appeared in the HBO limited series Mare of Easttown, a murder mystery, starring Kate Winslet.[19][20] Reviewing the latter film, Jordan Hoffman of Entertainment Weekly deemed Spaeny "the finest weapon in the arsenal... differentiating herself quite a bit from the doe-eyed characters she played in Civil War and Priscilla."[21] Spaeny will next star in the mystery film Wake Up Dead Man, the third installment of the Knives Out series, set for a Netflix release in 2025.[22] In 2024, she joined the cast for the second season of Netflix's anthology series Beef, alongside Oscar Isaac, Carey Mulligan, and Charles Melton.