WY-46824
WY-46824 is a norepinephrine-dopamine reuptake inhibitor related to venlafaxine.It was disclosed by Paige Mahaney and colleagues from Wyeth in 2008.[1] The compound was mentioned in an earlier article from 2007 but was not the main focus of that study.The racemic mixture of WY-46824 was resolved into its constituent enantiomers, with the (S)-enantiomer being the more active one.The N-desmethyl derivative of WY-46824 also shows similar activity.
IUPAC nameCAS NumberChemSpiderChEMBLCompTox DashboardFormulaMolar massSMILESnorepinephrine-dopamine reuptake inhibitorvenlafaxinenorepinephrine transporterdopamine transporterserotonin transporterPiperazinesAminoethylpiperazineDiethylcarbamazineMidafotelPiperazinePhenylpiperazines2C-B-PP3,4-CFPAcaprazineAntrafenineAripiprazoleBatoprazineBifeprunoxBRL-15,572CiprofloxacinCSP-2503DapiprazoleDiphenylpiperazineDropropizineEGIS-12,233ElopiprazoleEltoprazineEnpiprazoleEnsaculinEtoperidoneFlesinoxanFluanisoneFlibanserinFluprazineItraconazoleKetoconazoleLevodropropizineLorpiprazoleMefwayMepiprazoleNaftopidilNaluzotanNaphthylpiperazineNefazodoneNiaprazineOxypertinePardoprunoxPosaconazoleS-14,506S-14,671S-15,535SB-258,585SB-271,046SB-357,134SB-399,885SonepiprazoleTolpiprazoleTrazodoneUrapidilVesnarinoneVilazodoneVortioxetineWAY-100,135WAY-100,635Benzylpiperazines2C-B-BZP3-MethylbenzylpiperazineBefuralineBuclizineChlorbenzoxamineFipexideImatinibMeclozineMethoxypiperamideNSI-189PiberalinePiribedilSunifiramTrimetazidineDiphenylalkylpiperazinesAD-1211AlmitrineAmperozideBW373U86CetirizineChlorcyclizineCinnarizineClocinizineCyclizineDBL-583DiphenpipenolDiphenylmethylpiperazineDotarizineDPI-221DPI-287DPI-3290GBR-12,935HydroxyzineJJC8-088LidoflazineManidipineOxatomideSNC-80VanoxerinePyrimidinylpiperazinesBuspironeDasatinibEptapironeGepironeIpsapironePyrimidinylpiperazineRevospironeTandospironeTirilazadTrimazosinUmespironeZalospirone