Manidipine
Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.[6] The alkylation between N-(2-hydroxyethyl)piperazine [103-76-4] (1) and Benzhydryl Bromide [776-74-9] (2) gives 2-(4-benzhydrylpiperazin-1-yl)ethanol [10527-64-7] (3).The reaction with Diketene [674-82-8] (4) gives 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate [89226-49-3] (5).The reaction with 3-nitrobenzaldehyde [99-61-6] (6) and Methyl 3-aminocrotonate [14205-39-1] (7) completed the synthesis of Manidipine (8).This drug article relating to the cardiovascular system is a stub.
Drugs.comRoutes ofadministrationATC codeC08CA11Legal statusIUPAC nameCAS NumberChemSpiderCompTox DashboardFormulaMolar massSMILEScalcium channel blockerantihypertensiveIon channel modulatorsCalciumBlockersL-type-selectiveDihydropyridinesAmlodipineAranidipineAzelnidipineBarnidipineClevidipineDarodipineFelodipineIsradipineLacidipineLercanidipineLevamlodipineMepirodipineNicardipineNifedipineNiguldipineNiludipineNilvadipineNimodipineNisoldipineNitrendipineOxodipinePranidipineRyodipine (riodipine)DiltiazemClentiazemPhenylalkylaminesAnipamilDevapamilEmopamilFalipamilGallopamilNorverapamilTiapamilVerapamilAH-1058BudiodaroneCelivaroneCyproheptadineDronedaroneFantofaroneTetrahydropalmatineN-type-selectiveω-ConotoxinsCaroverineLeconotide (ω-conotoxin CVID)RalfinamideSafinamideZiconotide (ω-conotoxin MVIIA)P-type-selectiveR-type-selectiveSNX-482T-type-selectiveNiflumic acidZonisamideBenidipineBepridilCilnidipineCinnarizineDotarizineEfonidipineFlunarizineLamotrigineLevetiracetamLomerizineLoperamideMibefradilRuthenium redTROX-1gabapentinoids4-MethylpregabalinArbaclofenArbaclofen placarbilAtagabalinBaclofenGabapentinGabapentin enacarbilImagabalinMirogabalinPD-217,014PhenibutPregabalinBencyclaneBerbamineBevantololCanadineCarboxyamidotriazoleCycleanineDauricineDimeditiapramineDiproteverineEnpiperateEperisoneEthadioneEthanol (alcohol)EthosuximideFasudilFendilineFostedilImepitoinJTV-519LidoflazineMagnesiumManoalideMesuximideMonatepilNaftopidilOchratoxin A