[5][6] In 2001, she signed an agreement with BMG Entertainment and became the lead singer of La Quinta Estación,[7] with which she managed to achieve success in Spain, Mexico and the United States thanks to the albums Flores de Alquiler, El Mundo Se Equivoca y Sin Frenos.[13] In 2019, she released the single "Nunca Es Tarde", which she recorded with Jesús Navarro, vocalist of Reik, and composed with Claudia Brant and Jayson DeZuzio.In seven months, the material reached the top positions in the lists of musical successes in Mexico and the United States, and it has earned it a Gold Record and more than 55 million reproductions worldwide.[15] México de mi corazón is an album that honors the Mexican song and features duets with voices such as Carlos Rivera, Pedro Fernández, Paquita la del Barrio, Lila Downs, El Bebeto and Banda MS. Mariachi Gama Mil provides musical accompaniment, and Natalia was granted permission to incorporate choirs with Juan Gabriel.In 2020, Natalia returned to Spain where she served as judge of the reality show Operación Triunfo..[17] In 2021, she was on the Colombian Kids and Senior version of La Voz, winning both of the series.