Tony Shalhoub, Bitty Schram, Ted Levine, and Jason Gray-Stanford reprised their roles as the main characters.All of the main cast from the first season returned: Tony Shalhoub as Adrian Monk, the "defective detective"; Bitty Schram as Sharona Fleming, Monk's forceful nurse and assistant; Ted Levine as Captain Leland Stottlemeyer of the SFPD; and Jason Gray-Stanford as Lieutenant Randy Disher.Guest stars for the season included Glenne Headly in two episodes as Karen Stottlemeyer, Leland's wife, and Jarrad Paul as Monk's annoying upstairs neighbor, Kevin Dorfman.John Turturro guest starred as Monk's agoraphobic brother, Ambrose, a role that would later win him an Emmy.Amy Sedaris reprised her role as Gail Fleming, and Sarah Silverman made her debut as Monk's biggest fan, Marci Maven.