Microtubule organizing center
The MTOC is a major site of microtubule nucleation and can be visualized in cells by immunohistochemical detection of γ-tubulin.[1] In animals, the two most important types of MTOCs are 1) the basal bodies associated with cilia and flagella and 2) the centrosome associated with spindle formation.Other arrangements range from fungi spindle pole bodies to the eukaryotic chromosomal kinetochores (flat, laminated plaques).The MTOC is made up of a pair of centrioles at its center, and is surrounded by pericentriolar material (PCM) that is important for microtubule nucleation.As with the centrosome, these MTOCs stabilize and give direction to the microtubules, in this case to allow unidirectional movement of the cilium itself, rather than vesicles moving along it.[4] Instead, the nuclear envelope itself appears to function as the main MTOC for microtubule nucleation and spindle organization during plant cell mitosis.
eukaryoticmicrotubulesflagellamitoticmeioticspindle apparatuschromosomescell divisionmicrotubule nucleationimmunohistochemicalkingdomsbasal bodiescentrosome9+2 axonemebronchiolarkinetochoresCentriolesinterphasenucleusGolgi apparatuspericentriolar materialmotor proteinskinesindyneinendoplasmic reticulumCentrosomesγ-tubulinBasal bodySpindle pole bodyyeastsnuclear envelopeconifersflowering plantsT cellsnatural killer cellsMedical Subject HeadingsorganellesEndomembrane systemCell membraneParenthesomeAutophagosomeVesicleExosomeLysosomeEndosomePhagosomeVacuoleAcrosomeCytoplasmic granuleMelanosomeMicrobodyGlyoxysomePeroxisomeWeibel–Palade bodyCytoskeletonMicrofilamentIntermediate filamentMicrotubuleProkaryotic cytoskeletonCentrioleMyofibrilUndulipodiumCiliumAxonemeRadial spokePseudopodiumLamellipodiumFilopodiumEndosymbiontsMitochondrionPlastidChloroplastChromoplastGerontoplastLeucoplastAmyloplastElaioplastProteinoplastTannosomeApicoplastNitroplastNucleolusRibosomeSpliceosomeCytoplasmCytosolInclusionsProteasomeMagnetosomeCell wallExtracellular matrix