Folinic acid
[6] Folinic acid is given following methotrexate as part of a total chemotherapeutic plan, where it may protect against bone marrow suppression or gastrointestinal mucosa inflammation.This includes reductions in nausea, abdominal pain, abnormal liver blood tests, and mouth sores.Folinic acid is also sometimes used to prevent toxic effects of high doses of antimicrobial dihydrofolate reductase inhibitors such as trimethoprim and pyrimethamine, although its value for this indication has not been clearly established.[12] In pyridoxine-dependent epilepsy, folinic acid may be used as additional therapy if pyridoxine or pyridoxal phosphate fails to fully control the seizures.Since it does not require the action of dihydrofolate reductase for its conversion, its function as a vitamin is unaffected by inhibition of this enzyme by drugs such as methotrexate.[17] Folinic acid, therefore, allows for some purine/pyrimidine synthesis to occur in the presence of dihydrofolate reductase inhibition, so some normal DNA replication processes can proceed.[19] Folinic acid was discovered as a needed growth factor for the bacterium Leuconostoc citrovorum in 1948, by Sauberlich and Baumann.
folic acidDrugs.comMedlinePlusLicense dataDailyMedPregnancycategoryRoutes ofadministrationIntravenousATC codeV03AF03Legal status℞-onlyPharmacokineticBioavailabilityProtein bindingElimination half-lifeExcretionKidneyIUPAC nameCAS NumberIUPHAR/BPSDrugBankChemSpiderChEMBLCompTox DashboardECHA InfoCardFormulaMolar massMelting pointSolubility in waterSMILESmethotrexatepyrimethamine5-fluorouracilcolorectal cancerfolate deficiencyanemiamethanol poisoninginjection into a muscleinjection into a veinallergic reactionspregnancybreastfeedingpernicious anemiadihydrofolate reductaseWorld Health Organization's List of Essential Medicinesbone marrow suppressionnephrotoxicityrheumatoid arthritiscolon cancerthymidylate synthaseantimicrobialtrimethoprimtoxoplasmosisretinitissulfadiazinecerebral folate deficiency5-MTHFpyridoxine-dependent epilepsypyridoxal phosphateintrathecallyhypersensitivityFluorouracilenterocolitisSulfamethoxazole-trimethoprimPneumocystis jiroveciitetrahydrofolic acid5,10-methylenetetrahydrofolate5-methyltetrahydrofolateinhibitionpolyglutamylationpurinepyrimidineLeuconostoc citrovorumvitamercalciumsodiumWorld Health OrganizationDetoxifyingchemotherapyUric acidRasburicaseAcroleinnitrogen mustardsanthracyclinesDexrazoxaneAlkylating agentsAmifostineKeratinocyte growth factorPaliferminArginine/lysineGlucarpidaseTrilaciclibVitaminsα-Caroteneβ-CaroteneRetinolTretinoinErgosterolErgocalciferol7-DehydrocholesterolPrevitamin D3Cholecalciferol25-hydroxycholecalciferolCalcitriol (1,25-dihydroxycholecalciferol)Calcitroic acidDihydroergocalciferolAlfacalcidolDihydrotachysterolCalcipotriolTacalcitolParicalcitolTocopherolTocotrienolTocofersolanNaphthoquinonePhylloquinone (K1)Menaquinones (K2)Menadione (K3)Various (K4)4-Amino-2-methyl-1-naphthol (K5)2-Methylnaphthalene-1,4-diamine (K6)4-Amino-3-methyl-1-naphthol (K7)ThiamineB1 analoguesAcefurtiamine