[2][3][4] Joseph was married in San Francisco, California, to Ellen or Elena de Pedrorena of San Diego, California, and they had ten or eleven children, including Joseph W. Jr. (died June 1944), William F., David and John, who were educated at home.He "introduced scientific methods into the culture of oranges and extended the original Wolfskill grove until it was made to yield .The Wolfskill property in Los Angeles proper occupied the land later given over to the Arcade Depot.He had a nursery at the corner of Wabash and Zonal streets in Brooklyn Heights, Los Angeles, along with a retail store at 218 West Fourth Street in downtown L.A.[2][3][4] [11] An influx of white-scale insects from Australia devastated the orchards, and so Joseph Wolfskill divided the acreage and sold it piecemeal, in the meantime establishing an experimental station to devise a method of fighting the disease, including the use of "washes, sprays, gases, and latterly the parasites of the white scale[,] which have been brought from Australia.One subdivision became Chapman Woods, Pasadena, and Louis also owned Rancho San Francisquito, previously the property of his father-in-law, Henry Dalton.