Hexamidine
Hexomedine is the trade name of a diisethionate solution (1/1.000) of hexamidine.[1] Hexamidine is used primarily as its diisethionate salt, which is more water-soluble than the dihydrochloride.The exact mechanism of its biocidal action is unknown, but presumed similar to quaternary ammonium compounds, involving binding to the negatively charged lipid membranes of pathogens.Hexamidine and its shorter congener, propamidine, are used as antiseptics and preservatives in pharmaceuticals and cosmetics.They are particularly used for the topical treatment of acanthamoebiasis (Acanthamoeba keratitis).
Preferred IUPAC nameCAS NumberChEMBLChemSpiderDrugBankPubChemCompTox DashboardSMILESChemical formulaMolar massATC codeD08AC04R01AX07R02AA18S01AX08S03AA05standard stateantisepticdisinfectantdiisethionatetrypanocideMay & Bakeramoebicidalquaternary ammonium compoundslipid membranespropamidineAcanthamoeba keratitisAntisepticsdisinfectantsAcridineEthacridine lactate9-AminoacridineEuflavineBiguanidesamidinesDibrompropamidineChlorhexidinePolihexanidePhenolHexachlorophenePolicresulenTriclosanTriclocarbanChloroxylenolBiphenylolFenticlorNitrofuranNitrofurazoneIodineIodine/octylphenoxypolyglycoletherPovidone-iodineDiiodohydroxypropaneQuinolineDequaliniumChlorquinaldolOxyquinolineClioquinolBenzalkoniumBenzethonium chlorideCetrimoniumbromidechlorideCetylpyridiniumCetrimideBenzoxonium chlorideDidecyldimethylammonium chlorideMercurialMercuric amidochloridePhenylmercuric borateMercuric chlorideMerbrominNitromersolThiomersalMercuric iodideSilverSilver nitrateAlcoholsPropanol (propyl alcohol)Isopropanol (isopropyl alcohol)Ethanol (ethyl alcohol)Potassium permanganateSodium hypochloriteHalazoneMonalazoneHydrogen peroxideChloramine-T (tosylchloramide)Octenidine dihydrochlorideWHO-EMWithdrawnClinical trialsdermatologic