HLA-B27

[9] HLA-B27 is implicated in other types of seronegative spondyloarthropathy, such as reactive arthritis, acute anterior uveitis, iritis, Crohn's and ulcerative colitis associated spondyloarthritis.The arthritogenic peptide hypothesis suggests that HLA-B27 has a unique ability to bind antigens from a microorganism that triggers a CD8 T-cell response that cross-reacts with a HLA-B27/self-peptide pair.[14] The molecular mimicry hypothesis is similar, although it suggests that cross-reactivity between some bacterial antigens and self-peptides can break tolerance and lead to autoimmunity.Cross-display is proposed to lead to the formation of large, soluble, high molecular weight (HMW), degradation-resistant, long-surviving aggregates of the HLA-B27 heavy chain.Together with any homodimers formed either by cross-display or by a disulfide-linked homodimerization mechanism, it is proposed that such HMW aggregates survive on the cell surface without undergoing rapid degradation, and stimulate an immune response.
HLA-B*2705-peptide (chain A shown in green cartoon, chain B shown in yellow cartoon) complexed to a fragment of the influenza nucleoprotein NP383-391 (orange, sticks). PDB ID 2BST
EBI-HLAWayback Machinemajor histocompatibility complexchromosome 6peptidesT cellsankylosing spondylitispsoriatic arthritisinflammatory bowel diseasereactive arthritisChineseJapaneseScandinaviaSápmidiseasespathologygenotypeseronegative spondyloarthropathyuveitisiritisCrohn'sulcerative colitisautismCD8 T-cellβ2 microglobulinunfolded protein responseendoplasmic reticulumlong-term nonprogressorsHLA-B5701Human leukocyte antigenNational Institute of Allergy and Infectious DiseaseseMedicineOnline Mendelian Inheritance in ManMedical Subject Headingsserotypesallele