Gardner's syndrome

[5] There is no cure at this time, and in its more advanced forms, it is considered a terminal diagnosis with a life expectancy of 35–45 years; treatments are surgery and palliative care, although some chemotherapy has been tried with limited success.[3] This gene is also mutant in familial adenomatous polyposis (FAP), a more common disease that also predisposes to colon cancer.Gardner syndrome is set apart as a subtype because, in addition to colonic polyps, there are also extra-colonic growths (both malignant and benign).Gardner syndrome is also associated with familial adenomatous polyposis and may manifest as aggressive fibromatosis (desmoid tumors) of the retroperitoneum.Treatments for desmoid tumors may include surgery, NSAIDS, anti-estrogen medications, radiation therapy and chemotherapy.

Gardner syndrome has an autosomal dominant pattern of inheritance.

SpecialtyGastroenterologyoncologymedical geneticsfamilial adenomatous polyposisautosomaldominantpolyposispolypsosteomasthyroid cancerepidermoid cystsfibromasdesmoid tumorscolon cancerduodenumspleenkidneysmesenterycerebellumthyroidpalliative carechemotherapymutationadenomatous polyposis colichromosomephenotypicautosomal dominantgastrointestinal tractGardner fibromasperiampullary carcinomaschromosome 5impactedsupernumerary teethodontomasaponeurosisGorlin syndromeList of cutaneous conditionsList of dental abnormalities associated with cutaneous conditionsList of cutaneous neoplasms associated with systemic syndromesOnline Mendelian Inheritance in ManDiseasesDBMedlinePluseMedicineOrphanetRare DiseasesDigestive system neoplasiaGI tractEsophagusSquamous cell carcinomaAdenocarcinomaStomachGastric carcinomaSignet ring cell carcinomaGastric lymphomaMALT lymphomaLinitis plasticaHereditary diffuse gastric cancerSmall intestineDuodenal cancerAppendixCarcinoidPseudomyxoma peritoneiColon/rectumColorectal polypadenomahyperplasticjuvenilesessile serrated adenomatraditional serrated adenomaPeutz–JeghersCronkhite–CanadaMUTYH-associatedFamilial adenomatousPolymerase proofreading-associatedSerrated polyposisHereditary nonpolyposis colorectal cancerGastrointestinal stromal tumorKrukenberg tumor (metastatic)AccessorymalignantHepatocellular carcinomaFibrolamellarHepatoblastomaLiver angiosarcomabenignHepatocellular adenomaCavernous hemangiomahyperplasiaFocal nodular hyperplasiaNodular regenerative hyperplasiaBiliary tractbile ductCholangiocarcinomaKlatskin tumorgallbladderGallbladder cancerPancreasexocrine pancreasPancreatic ductal carcinomacysticneoplasmsSerous microcystic adenomaIntraductal papillary mucinous neoplasmMucinous cystic neoplasmSolid pseudopapillary neoplasmPancreatoblastomaPeritoneumPrimary peritoneal carcinomaPeritoneal mesotheliomaDesmoplastic small round cell tumorCytoskeletalMicrofilamentsMyofilamentHypertrophic cardiomyopathy 11Dilated cardiomyopathy 1AADFNA20Nemaline myopathy 3MyosinElejalde syndromeHypertrophic cardiomyopathy 1, 8, 10Usher syndrome 1BFreeman–Sheldon syndromeDFN A3, 4, 11, 17, 22; B2, 30, 37, 48May–Hegglin anomalyTroponinHypertrophic cardiomyopathy 7, 2Nemaline myopathy 4, 5TropomyosinHypertrophic cardiomyopathy 3Nemaline myopathy 1Hypertrophic cardiomyopathy 9FibrillinMarfan syndromeWeill–Marchesani syndromeFilaminFG syndrome 2Boomerang dysplasiaLarsen syndromeTerminal osseous dysplasia with pigmentary defectsKeratinopathykeratosiskeratodermahyperkeratosisStriate palmoplantar keratoderma 3Epidermolytic hyperkeratosisIchthyosis bullosa of SiemensMeesmann juvenile epithelial corneal dystrophyWhite sponge nevusEpidermolysis bullosa simplexFamilial cirrhosisSteatocystoma multiplexMonilethrixNaegeli–Franceschetti–Jadassohn syndromeReticular pigmented anomaly of the flexuresDesminDesmin-related myofibrillar myopathyDilated cardiomyopathy 1IAlexander diseasePeripherinAmyotrophic lateral sclerosisNeurofilamentParkinson's diseaseCharcot–Marie–Tooth disease 1F, 2ELaminopathyMandibuloacral dysplasiaDunniganFamilial partial lipodystrophyEmery–Dreifuss muscular dystrophy 2Limb-girdle muscular dystrophy 1BCharcot–Marie–Tooth disease 2B1Barraquer–Simons syndromeBuschke–Ollendorff syndromeOsteopoikilosisPelger–Huet anomalyHydrops-ectopic calcification-moth-eaten skeletal dysplasiaMicrotubulesKinesinCharcot–Marie–Tooth disease 2AHereditary spastic paraplegia 10DyneinPrimary ciliary dyskinesiaShort rib-polydactyly syndrome 3Asphyxiating thoracic dysplasia 3TauopathyCavernous venous malformationMembraneSpectrinSpinocerebellar ataxia 5Hereditary spherocytosis 2, 3Hereditary elliptocytosis 2, 3AnkyrinLong QT syndrome 4Hereditary spherocytosis 1CateninplakoglobinNaxos syndromeGiant axonal neuropathydesmoplakin