Dysphoria
Dysphoria (from Ancient Greek δύσφορος (dúsphoros) 'grievous'; from δυσ- (dus-) 'bad, difficult' and φέρω (phérō) 'to bear') is a profound state of unease or dissatisfaction.In a psychiatric context, dysphoria may accompany depression, anxiety, or agitation.[1] Intense states of distress and unease increase the risk of suicide, as well as being unpleasant in themselves.[citation needed] The 11th revision of the International Classification of Diseases (ICD-11) defines dysphoria as "an unpleasant mood state, which can include feelings of depression, anxiety, discontent, irritability, and unhappiness.The following conditions may include dysphoria as a symptom: Some drugs can produce dysphoria, including κ-opioid receptor agonists like salvinorin A (the active constituent of the hallucinogenic plant Salvia divinorum), butorphanol and pentazocine,[8] μ-opioid receptor antagonists such as naltrexone and nalmefene,[9] and antipsychotics like haloperidol and chlorpromazine (via blockade of dopamine receptors),[10] among others.