Desmocollin
[3][4] They are co-expressed with desmogleins to link adjacent cells by extracellular adhesion.Additionally, the 'a' form has an intracellular cadherin-like sequence domain, which provides binding sites for other desmosomal proteins such as plakoglobin.[4] Desmosomes are involved in cell-cell adhesion, and are particularly important for the integrity of heart and skin tissue.Because of this, desmocollin gene mutations can affect the adhesion of cells that undergo mechanical stress, notably cardiomyocytes and keratinocytes.Genetic disorders associated with desmocollin gene mutations include Carvajal syndrome, striate palmoplantar keratoderma, Naxos disease, and arrhythmogenic right ventricular cardiomyopathy.
cadherinsdesmosomesdesmogleinsisoformsDesmocollin-2C-terminusalternative splicingextracellulardomainsintracellularbinding sitesplakoglobinepidermiscardiomyocyteskeratinocytesCarvajal syndromepalmoplantar keratodermaNaxos diseasearrhythmogenic right ventricular cardiomyopathyautoimmunityinflammationantibodiesDesmogleinArmadilloPlakophilinPlakinDesmoplakinList of target antigens in pemphigusList of conditions caused by problems with junctional proteinsBibcodeMedical Subject HeadingsMembrane proteinscell adhesion moleculesIgSF CAMMyelin protein zeroVCAM-1PE-CAML1 familyL1-CAMNectinIntegrinsIntegrin alphaXbeta2Macrophage-1 antigenGlycoprotein IIb/IIIaITGA2BDesmosomalProtocadherinPCDH15PCDH19T-cadherinSelectinsE-selectinL-selectinP-selectinLymphocyte homing receptorintegrinCarcinoembryonic antigen