Cadusafos

Cadusafos (2-[butan-2-ylsulfanyl(ethoxy)phosphoryl]sulfanylbutane) is a chemical insecticide and nematicide often used against parasitic nematode populations.The compound is highly toxic to nematodes, earthworms and birds but poses no carcinogenic risk to humans.[1][2][3][4][5][6] A patent application for Cadusafos was first filed in Europe on August 13, 1982 by FMC Corporation, an American chemical company which originated as an insecticide producer.[8] However, the pesticide is not approved for use in Europe due to the lack of information on consumer exposure and the risk to groundwater.[9] Cadusafos is a synthetic organic thiophosphate compound which is observed as a volatile and persistent clear liquid.[2][17] A different study was performed in order to identify the metabolites formed in rats after receiving either an oral or intravenous dose of Cadusafos.[2] A study has been conducted by the Joint FAO/WHO Meeting on Pesticide Residues (JMPR), on rats in which the lethal dose of Cadusafos was investigated.[3] Besides its direct toxicity to multiple species, Cadusafos also has a potential to bioaccumulate so secondary poisoning for earthworm eating mammals and birds should also be taken into consideration.A multigeneration study in rats has established a No Adverse Effect Level (NOAEL) of 0.03 mg/kg bw per day for the inhibition of cholinesterase activity in plasma and erythrocytes.
Legal statusPharmacokineticBioavailabilityMetabolismMetabolitesElimination half-lifeExcretionIUPAC nameCAS NumberChemSpiderChEMBLCompTox DashboardECHA InfoCardFormulaMolar massDensityBoiling pointSolubility in waterSMILESinsecticidenematicideparasiticacetylcholinesterase inhibitorthiophosphatesEuropean Commissioninhalationingestionnematodesearthwormscarcinogenicpatent applicationFMC CorporationSigma Aldrichsynthetic organicthiophosphatevolatileorganothiophosphatephosphorussulphurcholinergic agentsreactivitycholinesterasenerve gassesmalathionsubstitution reactioninhibitoracetylcholinesterasecholineacetateneurotransmitterneural stimulusactive siteaccumulationrespiratory failureorganophosphatesanionicserinephosphorylateradiolabeledorallyabsorbedeliminatedintravenous1H-NMRsulfonic acidsconjugateslethal dosedermalUnited States Environmental Protection Agencyaquatic invertebratesarthropodsbioaccumulatesecondary poisoningplasmaerythrocytesgenotoxicnematodeRotylenchulus reniformisMeloidogyne incognitaendoparasiticectoparasitictriazophosmethyl bromidealdicarbcarbofuranphoratedosageEfficacyBibcodeFMC Corp.