Aminohippuric acid

It is an amide derivative of the amino acid glycine and para-aminobenzoic acid that is not naturally found in humans; it needs to be IV infused before diagnostic use.PAH is useful for the measurement of renal plasma flow.[1] The renal extraction ratio of PAH in a normal individual is approximately 0.92.[2] This means that unlike inulin and creatinine, which are filtered in the glomerulus and ignored by the rest of the kidney, aminohippuric acid is both filtered and secreted, being almost entirely removed from the bloodstream in a normal kidney.Transporters found in the kidney eliminate organic anions and cations from the blood by moving substances, in this case, drug metabolites, from blood into urine.
ATC codeV04CH30IUPAC nameCAS NumberIUPHAR/BPSDrugBankChemSpiderChEMBLNIAID ChemDBCompTox DashboardECHA InfoCardFormulaMolar massSMILEShippuric acidkidneyrenal plasma flowamino acidglycinepara-aminobenzoic acidrenal extraction ratioinulincreatinineglomerulussodiumPAH clearanceOrtho-iodohippurateDiagnosticDigestive systemDiabetesGlucoseTolbutamideFat absorptionVitamin ABile ductCeruletideMagnesium sulfateSincalideSorbitolLiver functional capacityGalactoseSulfobromophthaleinGastric secretionBetazoleCaffeinesodium benzoateCation exchange resinsHistamine phosphateMethylthioninium chloridePentagastrinpancreatic functionBentiromidePancreozymincholecystokininSecretinEndocrine systemPituitarycortisolCorticorelinMetyraponePralmorelinSermorelinSomatorelinThyroid functionProtirelinThyrotropinFertility disturbancesGonadorelinTuberculosisTuberculinRenal functionAlsactideIndigo carminepolyfructosansPhenolsulfonphthaleinPhysiology of the kidneysacid–base physiologyClearancePharmacokineticsClearance of medicationsUrine flow rateSolvent dragChlorideOligopeptidesProteinFiltrationRenal blood flowUltrafiltrationCountercurrent exchangeFiltration fractionAntidiuretic hormoneAldosteroneAtrial natriuretic peptideErythropoietinCalcitriolProstaglandinsFluid balanceBody waterIntracellular fluid/CytosolExtracellular fluidInterstitial fluidPlasmaTranscellular fluidAcid–base balanceDarrow Yannet diagramBase excessDavenport diagramAnion gapDelta ratioWinters's formulaBicarbonate buffer systemRespiratory compensationRenal compensationAssessment and measurementGlomerular filtration rateCreatinine clearanceAugmented renal clearanceRenal clearance ratioUrea reduction ratioStandardized Kt/VDialysis adequacyHemodialysis productEffective renal plasma flowExtraction ratioFractional excretion of sodiumBUN-to-creatinine ratioTubuloglomerular feedbackNatriuresis