Acyl carrier protein

The acyl carrier protein (ACP) is a cofactor of both fatty acid and polyketide biosynthesis machinery.[1] In both cases, the growing chain is bound to the ACP via a thioester derived from the distal thiol of a 4'-phosphopantetheine moiety.The ACPs are small negatively charged α-helical bundle proteins with a high degree of structural and amino acid similarity.The structures of a number of acyl carrier proteins have been solved using various NMR and crystallography techniques.The ACPs are related in structure and mechanism to the peptidyl carrier proteins (PCP) from nonribosomal peptide synthases.
Streptomyces coelicoloractinorhodinInterProPROSITEPDBsumfatty acidpolyketidephosphopantetheinenonribosomal peptideacyl carrier protein synthase4'-phosphopantetheinyl transferasefatty acid synthasespolyketide synthasesnonribosomal peptide synthetasesMedical Subject HeadingsProteinscarrier proteinspeptide hormoneFollistatinGrowth hormone binding proteinInsulin-like growth factor binding proteinIGFBP1IGFBP2IGFBP3IGFBP4IGFBP5IGFBP6IGFBP7NeurophysinsNeurophysin Isteroid hormoneSex hormone binding globulinAndrogen binding proteinTranscortinThyroxine-binding globulinTransthyretinCalcium-binding proteinCalmodulin-binding proteinsCeruloplasminIron-binding proteinsTransferrin receptorRetinol binding proteinTranscobalaminPigmentPlant Light-Harvesting ComplexOrange Carotenoid ProteinPhycobiliproteinPhotosynthetic Reaction CentersPhytochromeRhodopsinAdaptor proteinCholesterylester transfer proteinF-box proteinGTP-binding proteinLatent TGF-beta binding proteinMajor urinary proteinsMembrane transport proteinOdorant binding protein