Incumbent Democratic Senator Alex Padilla was appointed in 2021 by Governor Gavin Newsom to fill the vacancy created by Kamala Harris's election to the vice presidency in 2020, and he sought a full term.[9] Padilla's election strategy focused on advocating for progressive policies and building ties with left-wing organizations that had a poor relationship with California's other Senator, Dianne Feinstein.[9][44] The potential Democratic opponent to Padilla considered most likely to join the race was U.S. Representative Ro Khanna, a staunchly left-wing Democrat who rose to prominence as the co-chair of the Bernie Sanders 2020 presidential campaign, and who had a loyal base of support from California's Asian-American and Pacific Islander communities.[45] It was noted by the San Francisco Chronicle that it was considered unlikely that Padilla would face any serious Republican opponent, as California's heavily Democratic lean caused potentially strong candidates, such as U.S.Representatives Mike Garcia and Young Kim, to prefer to remain in their positions rather than launch a long-shot Senate run.