The highway begins at an intersection with US 83 in Carrizo Springs, about 60 miles northwest of Laredo.On the outskirts of Randlett, this ends as U.S. 277-281 turn northward and pass under I-44 (with no interchange there) before entering Cookietown.The route proceeds from there to serve several other towns bypassed by I-44, such as Fletcher, Cyril, and Cement, crossing the turnpike twice without direct access.Bailey Turnpike between Oklahoma City and the Red River from Newcastle southwest of Oklahoma to near Medicine Park north of Lawton and from near Geronimo south of Lawton to Randlett just north of the Red River near Burkburnett, Texas.The original northern terminus was in Oklahoma City at its intersection with parent route US 77 and US 62.[citation needed] On March 15, 2022, a bill was signed by President Joe Biden that added the extension of I-27 north to Raton, New Mexico, and south to Laredo to the Interstate Highway System.Present U.S. 281 Business and former U.S. 277-281 follows 2nd Street south of I-44 (Exit 39B) into the downtown area and south of Lee Boulevard (Oklahoma 7), curves into the diagonal route to 11th Street and still locally designated by the City of Lawton as Highway 277 even though it is officially designated as U.S. 281 Business.
First southbound sign for U.S. 277 in
Newcastle, Oklahoma
(US 277 sign has since been replaced with a newer version)