Stratum corneum

Corneodesmosomes (modified desmosomes) facilitate cellular adhesion by linking adjacent cells within this epidermal layer.[4] Cells of the stratum corneum contain a dense network of keratin, a protein that helps keep the skin hydrated by preventing water evaporation.The mechanical stress of heavy structural strain causes this stratum lucidum phase in these regions which require additional protection in order to grasp objects, resist abrasion or impact, and avoid injury.In reptiles, the stratum corneum is permanent, and is replaced only during times of rapid growth, in a process called ecdysis or moulting.For example, a failure to modulate the activity of kallikreins via the disruption of the protease inhibitor LEKTI causes the debilitating disorder Netherton syndrome.
Sampling of human stratum corneum using a tape-stripping method [ 1 ]
Micrograph showing prominent hyperkeratosis in skin without atypia . H&E stain .
HistologicepidermisAnatomical terminologyinfectiondehydrationkeratinceramidescholesterolfatty acidsDesquamationkeratinocytesstratum basalecorneocytesacid mantlecell membranedesmosomesproteasesproteinevaporationabsorbreptilesecdysismoultingbeta-keratinprotease inhibitorNetherton syndromeMicrographatypiaH&E stainHyperkeratosisEpidermis (skin)HexastixKallikrein-5Peeling skin syndromeStratum granulosumStratum spinosumScientific ReportsBibcodeMedEd at LoyolaSkin and related structuresStratum lucidumMalpighian layerBasement membraneBasal keratinocyteLamina lucidaLamina densaDermisPapillaryDermal papillaeReticularSubcutaneous tissuePanniculusPannusPanniculus adiposusPanniculus carnosusMembranous layerLoose connective tissueSuperficial fasciaAdnexaSkin glandsSweat glandsApocrine sweat glandEccrine sweat glandSebaceousRoot sheathOuter root sheathInner root sheathHenle's layerHuxley's layerHair shaftCuticleCortexMedullaBulb with matrix cellsHair follicleMuscleArrector pili musclePilosebaceous unitsebaceous glandNail matrixNail plateLunulaEponychiumParonychiumHyponychium