Sprague River is an unincorporated community in Klamath County, Oregon, United States.[2] It is about 45 miles (72 km) northeast of Klamath Falls near the Sprague River, northwest of Oregon Route 140.[6] Sprague River post office, named after the stream, was established September 14, 1923, with Benjamin E. Wolford as the first postmaster.[6] There was an earlier post office named Sprague River farther east and upstream of the current community, at the site of the current town of Bly, Oregon[6] Sprague River had a station on the Oregon, California and Eastern Railway,[6] which by 1927 reached from Klamath Falls to Bly.[8] After 1990, the rail line near Sprague River became part of a rail trail, the OC&E Woods Line State Trail, managed by the Oregon Parks and Recreation Department.