[1] The brothers Pietro and Ambrogio Lorenzetti were "responsible for a crucial development in Sienese art, moving from the tradition inherited from Duccio towards a Gothic style, incorporating the innovations in Florence introduced by Giotto and Arnolfo di Cambio".And while the artists of 15th-century Siena did not enjoy the widespread patronage and respect that their 14th-century ancestors had received, the paintings and illuminated manuscripts they produced form one of the undervalued treasures in the bounty of Italian art."[3] In the late 15th century, Siena "finally succumbed" to the Florentine school's teachings on perspective and naturalistic representation, absorbing its "humanist culture".While Baldassare Peruzzi was born and trained in Siena, his major works and style reflect his long career in Rome.[4] It also has "a mystical streak...characterized by a common focus on miraculous events, with less attention to proportions, distortions of time and place, and often dreamlike coloration".