Shuji Ogino
He is also Chief of Program in MPE Molecular Pathological Epidemiology at Brigham and Women's Hospital,[1] and an associate member of Broad Institute of MIT and Harvard.After postdoctoral fellowship at University of Pennsylvania, he joined Dana–Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School as Instructor in Pathology in 2001.Ogino became Chief of Program in MPE Molecular Pathological Epidemiology at Brigham and Women's Hospital in 2016, and an associate member of Broad Institute of MIT and Harvard in 2017.Utilizing tissue pathology resource and data within existing epidemiology studies, he has been publishing a large number of original articles proving the interrelationship between exposure to risk factors (e.g., environmental, dietary, lifestyle and genetic factors) and molecular pathologic signature of disease (e.g., PIK3CA mutation in colorectal cancer) including some of influential papers in the field,[24][25][26][27][28][29][30][31][32][33][excessive citations] as well as papers which have developed the concepts of MPE.His proposal for a transition from the two-colon concept (the proximal and distal colon)[49][50][51][52] to the colorectal continuum model[53] was supported by an observed linear relationship between the location on the colon and Microsatellite instability (MSI), CpG island methylator phenotype (CIMP) and BRAF mutation frequency from the database analyses of over 1,400 colorectal cancer cases.